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1. 中国科学院南海海洋研究所广东省海洋药物重点实验室
2. 中国科学技术大学化学系,广州,510301
3. ,合肥,230026
纸质出版日期:2004-02-01
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[1]王清吉,王友绍,何磊,宋钦华.茶多酚和银杏叶有效成分的抗辐射作用研究[J].核技术,2004(02):148-150.
WANG Qingji1 WANG Youshao1 HE Lei1 SONG Qinhua2 1. Antiradiation effect of tea polyphenol and effective components from ginkgo leaves[J]. Nuclear techniques, 2004, (2): 148-150.
将72只昆明种雄性小白鼠随机均分为 6 组,以 150 mg/kg 体重的药物量连续灌服 20d 后,用 Co γ射 60线全身照射,吸收剂量为 9 Gy,继续灌服药物 13d。与对照组相比,茶多酚组、银杏黄酮组、银杏内酯组、茶多酚+银杏内酯组和茶多酚+银杏黄酮组的存活率分别提高 66.6%、41.6%、75%、66.6%、75%。平均存活天数分别提高 2.9(P<0.01)、1.8(P<0.05)、3.2(P<0.01)、3.1(P<0.01)、3.1(P<0.01)。实验结果表明:茶多酚和银杏叶有效成分具有抗辐射作用,茶多酚的多酚性羟基和银杏内酯的多羟基以及内酯键并存可能是辐射保护作用的结构基础,不同物质所含结构相同或具有类似官能团是具有复合协同增效作用的前提。
In order to explore the antiradiation effect of tea polyphenol(TP) and ginkgo biloba leaves extracts
we have made an animal experiment. 6 groups of Kunming rats
12 rats in each group
were investigated. Except contrast group
other 5 groups were fed with different medicals for 20 d
then all 6 groups were irradiated by Co γ-rays of 960 Gy/min for one minute. After the irridiation the rats were continually fed with the same medicals for 13d. Meanwhile we observed and recorded the death number of each group day by day. Compared with contrast
the results showed that increased living ratios of tea polyphenol
flavonoids
ginkgolide
“TP plus ginkgolide” and “TP plus flavonoids” groups were 66.6%
41.6%
75%
66.6% and 75%
and their increased average living time were 2.9d (P<0.01)
1.8 d (P<0.05)
3.2 d (P<0.01)
3.1 d (P<0.01) and 3.1 d (P<0.01)
respectively. The experimental results indicate that tea polyphenol and ginkgo biloba extracts have an antiradiation ability
for the poly-hydroxyl of tea polyphenol
the hydroxyl and ester bond of ginkgolide are suspected to be the foundation of the ability. It is found that the coordination effect of two materials is stronger than any one alone as they have the same chemical structures or similar functional groups.
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