<sup>99m</sup>Tc标记“3+1”混合配体心血池显像剂的研究

吕恭序; 张亚东; 王学斌

doi:null

您当前的位置：

首页 >

文章列表页 >

^99mTc标记“3+1”混合配体心血池显像剂的研究

更新时间：2021-03-12

- ^99mTc标记“3+1”混合配体心血池显像剂的研究
- An investigation of ^99mTc-labeled"3+ 1" mixed ligand complexes as potential blood-pool imaging agents
- 核技术 2000年第11期
- 作者机构：
  
  北京师范大学,北京,100875
- 作者简介：
- 基金信息：
- DOI：
  中图分类号：
- 纸质出版日期：2000-11-01
- 稿件说明：
移动端阅览
[1]吕恭序,张亚东,王学斌.~(99m)Tc标记“3+1”混合配体心血池显像剂的研究[J].核技术,2000(11):786-791.

LU Gongxu, ZHANG Yadong, WANG Xuebin. An investigation of ^99mTc-labeled"3+ 1" mixed ligand complexes as potential blood-pool imaging agents[J]. Nuclear techniques, 2000, (11): 786-791.
[1]吕恭序,张亚东,王学斌.~(99m)Tc标记“3+1”混合配体心血池显像剂的研究[J].核技术,2000(11):786-791. DOI：

LU Gongxu, ZHANG Yadong, WANG Xuebin. An investigation of ^99mTc-labeled"3+ 1" mixed ligand complexes as potential blood-pool imaging agents[J]. Nuclear techniques, 2000, (11): 786-791. DOI：

摘要

合成了一种新的含有ＳＮＮ结构的三齿配体Ｎ＇－（２巯基－２－甲基异丙基）－Ｎ，Ｎ－二乙基乙二胺（ＭＤＥＤＡ）。用９９ｍＴｃ－葡庚糖配体交换法与不同的单齿硫酸制备了４种９９ｍＴｃ的“３＋１”混配配合物，标记率均大于９０％。对标记率的影响因素如ｐＨ、温度等作了探讨，并作了小鼠体内的分布实验和家兔的ＳＰＥＣＴ显像。实验表明这些配合物在血中的摄取和滞留远远超过了其他脏器，其中以配合物５ｃ的血滞留最好，有望达到血池显像剂的要求。

Abstract

A new tridentate N-(2-mercapto-2-methylpropyl)- N

N-diethylethylene diamine (MDEDA) containing the SNN donor was synthesized and characterized by IR and 1H NMR. The tridentate and various monodentate thiols using 99mTc(V)-gluconate as precusor

chelates to the TcO3+ core. Thus four "3 + 1

" mixed ligand complexes of general formula [TcO(Et2NCH2CH2 NCHC(CH3)2S] [SR] were prepared. The labeling efficiency were all higher than 90%. The effects of pH value

temperature and reaction time were studied. The biodistribution results in mice and rabbits indicated that the uptake and retention of these complexes in blood was much higher and longer than those in other organs. The retention of complex 5c can be retend in blood was longer than the retention of others. Perhaps it can satisfy the requirement of blood-pool imaging agent.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

¹³¹I-BmK CT的制备及其在胶质瘤荷瘤大鼠体内分布与显像研究

ICP-MS法研究3nm TiO₂的小鼠体内分布

¹²⁵I-白蛋白融合干扰素α2b大鼠体内分布研究

⁹⁹Tc^m-半乳糖基化人血清白蛋白融合干扰素α2b的制备和生物分布

苯甲酰胺类多巴胺D2受体显像剂¹⁸F-Fallypride的制备和生物分布

99mTc标记“3+1”混合配体心血池显像剂的研究

An investigation of 99mTc-labeled"3+ 1" mixed ligand complexes as potential blood-pool imaging agents

DOI：

摘要

Abstract

关键词

Keywords

references

^99mTc标记“3+1”混合配体心血池显像剂的研究

An investigation of ^99mTc-labeled"3+ 1" mixed ligand complexes as potential blood-pool imaging agents