CA-242和CA19-9测定对胆囊良恶性疾病的诊断以及高胆红素血症对测定的影响

朱翠英; 沈江帆; 黄钢; 袁济民

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CA-242和CA19-9测定对胆囊良恶性疾病的诊断以及高胆红素血症对测定的影响

更新时间：2021-03-12

- CA-242和CA19-9测定对胆囊良恶性疾病的诊断以及高胆红素血症对测定的影响
- The clinical value of CA-242 and CA19-9 immunoassay in differential diagnosis of benign and malignant gallbladder disease and the influence of hyperbilirubinemia
- 核技术 2003年第5期
- 作者机构：
  
  1. 上海第二医科大学附属仁济医院
  2. 上海市普陀区中心医院
  3. 上海第二医科大学附属仁济医院,上海,200001
  4. ,上海,200062
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R817.4
- 纸质出版日期：2003-05-01
- 稿件说明：
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[1]朱翠英,沈江帆,黄钢,袁济民.CA-242和CA19-9测定对胆囊良恶性疾病的诊断以及高胆红素血症对测定的影响[J].核技术,2003(05):367-370.

ZHU Cuiying1 SHEN Jiangfan2 HUANG Gang1 YUAN Jimin1 1. The clinical value of CA-242 and CA19-9 immunoassay in differential diagnosis of benign and malignant gallbladder disease and the influence of hyperbilirubinemia[J]. Nuclear techniques, 2003, (5): 367-370.
[1]朱翠英,沈江帆,黄钢,袁济民.CA-242和CA19-9测定对胆囊良恶性疾病的诊断以及高胆红素血症对测定的影响[J].核技术,2003(05):367-370. DOI：

ZHU Cuiying1 SHEN Jiangfan2 HUANG Gang1 YUAN Jimin1 1. The clinical value of CA-242 and CA19-9 immunoassay in differential diagnosis of benign and malignant gallbladder disease and the influence of hyperbilirubinemia[J]. Nuclear techniques, 2003, (5): 367-370. DOI：

摘要

报道了CA-242和CA19-9免疫测定对19例胆囊癌和205例良性胆囊疾病的诊断和鉴别诊断的临床价值。显示CA-242和CA19-9的敏感度分别为84.2%和94.7%;特异性为94.6%和72.7%;诊断符合率为93.8%和74.6%

CA-242测定的特异性和符合率均优于CA19-9。本文还探讨了高胆红素血症对CA-242和CA19-9测定的影响

通过对慢性肝病黄疸患者血清的测定和胆囊疾病胆汁和血清联合测定的比较后发现:高胆红素血症对CA19-9测定影响很大

是假阳性的主要原因

但对CA-242测定的影响则很小

因此

判断临床结果时

应高度重视高胆红素血症的影响。

Abstract

cases of cholecystic cancer and 205 cases of benign gall bladder diseases measured by CA 242 and CA19-9 immunoassay were reported. Sensitivity of CA 242 and CA19-9 was 84.2% and 94.7%

specificity was 94.6% and 72.7%

and concordance rate was 93.8 % and 74.6%

respectively. Therefore

specificity and concor-dance rate of CA 242 immunoassay was better than CA19-9. It has also been specially investigated the influence of hyperbilirubinemia on results of CA 242 and CA19-9 measurements. By measurements of the serum in patients of chronic liver diseases with jaundice

and also the combined measurement of both serum and bile in patients with gall bladder diseases

it was demonstrated that hyperbilirubinemia greatly affects the results of CA19-9 and therefore plays a main role for its false positivity

but has less effect on CA 242 determination. Thereby

when judging its clinical results

we must pay special attention to hyperbilirubinemia.

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