肉瘤间质内注射<sup>188</sup>Re一硫化铼混悬液的动物实验研究

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肉瘤间质内注射¹⁸⁸Re一硫化铼混悬液的动物实验研究

更新时间：2021-03-12

- 肉瘤间质内注射¹⁸⁸Re一硫化铼混悬液的动物实验研究
- Study on interstitial injection of ¹⁸⁸Re-sulfide suspension in sarcoma bearing mice
- 核技术 1999年第5期
- 作者机构：
  
  中国科学院上海原子核研究所,上海,201800
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R730.2
- 纸质出版日期：1999-05-01
- 稿件说明：
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[1]闵小锋,张炯,于俊峰,尹端沚,郭子丽,汪勇先.肉瘤间质内注射~(188)Re一硫化铼混悬液的动物实验研究[J].核技术,1999(05):293-296.

MIN Xiaofeng, ZHANG Jiong, YU Junfeng, et al. Study on interstitial injection of ¹⁸⁸Re-sulfide suspension in sarcoma bearing mice[J]. Nuclear techniques, 1999, (5): 293-296.
[1]闵小锋,张炯,于俊峰,尹端沚,郭子丽,汪勇先.肉瘤间质内注射~(188)Re一硫化铼混悬液的动物实验研究[J].核技术,1999(05):293-296. DOI：

MIN Xiaofeng, ZHANG Jiong, YU Junfeng, et al. Study on interstitial injection of ¹⁸⁸Re-sulfide suspension in sarcoma bearing mice[J]. Nuclear techniques, 1999, (5): 293-296. DOI：

将１８８Ｒｅ一硫化铼混悬液注射到荷瘤小鼠肉瘤中，结果约８０％－９０％的放射性积聚在肿瘤内；向瘤中心先后两次注射２１．２ＭＢｑ１８８Ｒｅ一硫化铼液后，能有效抑制肉瘤生长，并无明显毒副作用；注射１８８ｂｅ一硫化铼组小鼠外周血ＷＢＣ数尽管比其余组小鼠低，但仍在正常范围内，对骨髓无明显影响。

The 188Re-sulfide suspension was injected into sarcoma mice interstitially. The result showed that the ratio of uptake of sarcomas was about 80%-90%

and the growth of sarcoma was depressed in all mice. When 21.2MBq 188Re-sulfide suspension were injected twice in each mouse

no any toxic effect was found. The white blood cells(WBC) in mice injected with 188Re-sulfide suspension was less than those of the other groups

but still within the normal level. No significant effect to the bone marrow was observed.

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