The purpose of our work is to find a way for application of depleted uranium inCANDU reactor by using MOX nuclear fuel of depleted U and Pu instead of naturaIuranium. From preliminary evaluation and calculation
it was shown that MOXnuclear fuel consisting of depleted uranium enrichment tailings (0.25% 235U) andplutonium (their ratio 99.5%:0.5%) could replace natural uranium in CANDU reactorto sustain chain reaction. The prospects of application of depleted uranium in nuclearenergy field are also discussed.