Background: Recently

the most reductant widely used to partition plutonium from uranium in the Purex solvent extraction purification process have been salt-free reagents.Purpose: In order to determine the utility of sale-free reagents in the Purex solvent extraction process.Methods: The report is a review of the applications of sale-free reagents in the U/Pu separation process

such as hydroxylamine derivative

U(IV)

aldehyde derivative

hydrazine

hydroxyl carbamide

derivative

hydroxamic acid and so on.Results: In this review

we have investigated and summarized the previous works covering the thermodynamics and dynamics behaviors to offer references for the future R&D works on the capability of salt-free reagents in the PUREX process and to indicate its applications.Conclusions: Acetohydroxamic acid and hydroxysemicarbazide have the capability of stripping trace amount plutonium of uranium in the future industrialization.