Recent studies show that many neuropathies such as Alzheimer’s disease are associated with the aggregation in vivo of amyloid-like protein.While the aggregation progress depends on sequences of the amino acids

also it is closely related to the environmental factors such as metal ions

pH

temperature etc.In this paper

effect of Fe3+ ions on the aggregation is investigated by atomic force microscopy and micro-FTIR.The results show that the lag time of fibrillation is dramatically extended

and the second structure of formed fibrils changes

too

in glucagon mixed with Fe3+ions.It also suggests that such a change may depend on concentration of added Fe3+ions.