小肠原发恶性肿瘤<sup>18</sup>F-FDGPET/CT显像及诊断方法

谢昌辉; 尹吉林; 李向东; 王欣璐; 李兴耀; 全江涛

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小肠原发恶性肿瘤¹⁸F-FDGPET/CT显像及诊断方法

放射化学、放药和核医学 | 更新时间：2021-03-05

- 小肠原发恶性肿瘤¹⁸F-FDGPET/CT显像及诊断方法
- ¹⁸F-FDG PET/CT imaging and diagnosis method of small intestine primary malignant neoplasms
- 核技术 2012年35卷第3期
- 作者机构：
  
  1. 南方医科大学附属宝安医院核医学科
  2. 广州军区广州总医院核医学科
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R735.3
- 纸质出版日期：2012-03-01
- 稿件说明：
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[1]谢昌辉,尹吉林,李向东,王欣璐,李兴耀,全江涛.小肠原发恶性肿瘤~(18)F-FDGPET/CT显像及诊断方法[J].核技术,2012,35(03):216-221.

XIE Changhui1 YIN Jilin2 LI Xiangdong2 WANG Xinlu2 LI Xingyao2 QUAN Jiangtao2 1. ¹⁸F-FDG PET/CT imaging and diagnosis method of small intestine primary malignant neoplasms[J]. Nuclear techniques, 2012, 35(3): 216-221.
[1]谢昌辉,尹吉林,李向东,王欣璐,李兴耀,全江涛.小肠原发恶性肿瘤~(18)F-FDGPET/CT显像及诊断方法[J].核技术,2012,35(03):216-221. DOI：

XIE Changhui1 YIN Jilin2 LI Xiangdong2 WANG Xinlu2 LI Xingyao2 QUAN Jiangtao2 1. ¹⁸F-FDG PET/CT imaging and diagnosis method of small intestine primary malignant neoplasms[J]. Nuclear techniques, 2012, 35(3): 216-221. DOI：

摘要

44例小肠原发疾病患者（恶性25例

良性19例）18F-FDG PET/CT显像资料经组织学、诊断性治疗和/或临床随访证实;采用目测法、定量方法（测病变肠壁的厚度）及半定量方法[测平均标准摄取值（SUVmean）]分析PET/CT影像特点

以最大约登指数（YImax）时的SUVmean及肠壁厚度作为判断良恶性的阈值;以最后诊断结果为标准进行诊断学试验评价。结果显示:（1）小肠恶性肿瘤PET/CT表现为小肠局部肿块形成、局部肠壁增厚、肠管狭窄、肠梗阻及肠系膜淋巴结肿大等征象

而良性病变仅显示小肠肿块形成（χ2=10.40

p<0.01）、局部肠壁增厚（χ2=3.90

p<0.05）

二征象有显著性差异。（2）小肠良、恶性病变肠壁厚度分别为（7.53±3.24）mm、（14.24±2.02）mm（t=2.66

p<0.01）;YImax=0.589时

肠壁厚度为9.5 mm

诊断灵敏度、特异性和准确度分别为80.00%、78.95%和79.55%。（3）小肠良、恶性病变的SUVmean分别为3.55±1.84、6.98±3.62（t=3.77

p<0.01）;YImax=0.379时

SUVmean=3.65

诊断灵敏度、特异性和准确度分别为80.00%、58.85%和70.45%。（4）以小肠肿块形成作为恶性的判断标准

诊断的灵敏度、特异性和准确度分别为84.00%、78.95%和81.82%

YImax=0.630。（5）以小肠局部肿块形成及病灶SUVmean≥3.65、局部肠壁增厚及厚度≥9.50 mm为主要依据

诊断灵敏度、特异性和准确度分别为96.00%、89.47%和93.18%

YImax=0.855。表明18F-FDG PET/CT显像提示小肠局部肿块形成及病灶SUVmean≥3.65、局部肠壁增厚及厚度≥9.50 mm的定性定量征象对准确诊断小肠原发恶性肿瘤具有重要的临床价值。

Abstract

18F-FDG PET/CT data of 44 patients with small intestine disease(malignant

25;benign

19) were analyzed retrospectively.All results were proved by pathological

or diagnostic therapy and/or clinical follow-up.Visual and quantitative[intestinal wall thickness(IWT)] and semiquantitative methods [standardized uptake value(SUV)] were used to analyze the imaging features.The SUVmeanand IWT were taken as the diagnostic threshold value for malignant when the Youden’s index(YI) was maximum.The diagnostic test evaluation was compared with the final diagnostic results.The following results were obtained.(1) The 18F-FDG PET/CT imaging signs of small intestine carcinoma presented as intestinal local mass formation(84.00%)

local wall thickening(76.00%)

stenosis(25.00%)

obstruction(32.00%) and enlargement of mesenteric lymph nodes(72.00%).But the incidence rates of these signs in the benign lesions were 31.58%

42.11%

10.53%

15.79% and 52.63%

respectively.Only the signs of intestinal local mass formation(χ2=10.40

p<0.01) and local wall thickening(χ2=3.90

p<0.05) between intestinal malignant and benign lesions were of significant statistic difference.(2) The IWT of intestinal malignant and benign lesions was 7.53±3.24 mm and 14.24±2.02 mm(t=2.66

p<0.01)

respectively.When YImax =0.589

the diagnostic threshold of IWT was 9.5mm.The sensitivity

specificity and accuracy were 80.00%

78.95% and 79.55%

respectively.(3) The SUVmeanof intestinal malignant and benign lesions was 3.55±1.84 and 6.98±3.62(t=3.77

p<0.01) respectively.When YImax =0.379

the diagnostic threshold of SUVmean was 3.65.The sensitivity

specificity and accuracy were 80.00%

57.89% and 70.48%

respectively.(4) Taking the intestinal mass formation as the diagnostic standard of malignant lesions

the sensitivity

specificity and accuracy were 84.00%

78.95% and 81.82%

respectively.The YImax was 0.630.(5) Taking the intestinal mass formation and SUVmean of <3.65

and local wall thickening or IWT <9.50 mm as the main evidence of the intestinal malignant lesions

the sensitivity

specificity and accuracy were 96.00%

89.47% and 93.18%

respectively.The YImaxwas 0.855.It can be used as the main evidence to differentiate the small intestine primary malignant and benign lesion with the 18F-FDG PET/CT imaging qualitative and quantitative signs for the intestinal mass formation

at SUVmean<3.65

and local wall thickening or IWT <9.50 mm.

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小肠原发恶性肿瘤18F-FDGPET/CT显像及诊断方法

18F-FDG PET/CT imaging and diagnosis method of small intestine primary malignant neoplasms

DOI：

摘要

Abstract

关键词

Keywords

references

小肠原发恶性肿瘤¹⁸F-FDGPET/CT显像及诊断方法

¹⁸F-FDG PET/CT imaging and diagnosis method of small intestine primary malignant neoplasms