Folic acid receptor（FR） was usually overexpressed in many cancer cells and was considered as potential target for targeted therapy agent.We decorated dendrimer polyamidoamine generation five-folic with acid and 1B4M-DTPA and then radiolabeled with

188

Re.Thes in vitro stability was evaluated.The labeling yield of the G5-FA-DTPA-

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Re was 67.5%

with a radiochemical purity of over 95%.The conjugate also showed high in vitro stability.Further modifications on the dendrimer folic acid conjugate and biological evaluation is in progress and will be reported in due course.