<sup>11</sup>C-MET和<sup>18</sup>F-FDG PET/CT对胶质瘤诊断的价值比较

理东丽; 许乙凯; 王全师; 吴湖炳; 李洪生

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¹¹C-MET和¹⁸F-FDG PET/CT对胶质瘤诊断的价值比较

核化学、放射性药物和核医学 | 更新时间：2021-03-05

- ¹¹C-MET和¹⁸F-FDG PET/CT对胶质瘤诊断的价值比较
- Comparative PET/CT study with ¹¹C-MET and ¹⁸F-FDG for diagnosing Glioma
- 核技术 2011年34卷第2期
- 作者机构：
  
  1. 南方医科大学南方医院PET中心
  2. 南方医科大学南方医院影像中心
- 作者简介：
- 基金信息：
  
  国家自然科学基金（30370426、30870731）资助()
- DOI：
  中图分类号： R739.4
- 纸质出版日期：2011-02-01
- 稿件说明：
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[1]理东丽,许乙凯,王全师,吴湖炳,李洪生.~(11)C-MET和~(18)F-FDG PET/CT对胶质瘤诊断的价值比较[J].核技术,2011,34(02):151-155.

LI Dongli1, 2 XU Yikai2 WANG Quanshi1 WU Hubing1 LI Hongsheng1 1. Comparative PET/CT study with ¹¹C-MET and ¹⁸F-FDG for diagnosing Glioma[J]. Nuclear techniques, 2011, 34(2): 151-155.
[1]理东丽,许乙凯,王全师,吴湖炳,李洪生.~(11)C-MET和~(18)F-FDG PET/CT对胶质瘤诊断的价值比较[J].核技术,2011,34(02):151-155. DOI：

LI Dongli1, 2 XU Yikai2 WANG Quanshi1 WU Hubing1 LI Hongsheng1 1. Comparative PET/CT study with ¹¹C-MET and ¹⁸F-FDG for diagnosing Glioma[J]. Nuclear techniques, 2011, 34(2): 151-155. DOI：

摘要

对26例胶质瘤和18例颅内良性病变患者行18F-FDG和11C-MET PET/CT颅脑显像

定性和半定量分析两种显像图像。结果显示:11C-MET和18F-FDG PET/CT对胶质瘤诊断的准确率分别为88.6%和65.9%。半定量分析

26例胶质瘤11C-MET摄取值比值T/NGmax显著高于18F-FDG的T/NGmax（1.95±0.52 vs 0.90±0.27

t=9.101

P<0.001）。11C-MET和18F-FDG对高级别胶质瘤诊断的灵敏度无显著差异（100%vs.64.3%;χ2=3.20

P>0.05）;对低级别胶质瘤诊断的灵敏度11C-MET（83.3%）高于18F-FDG（33.3%

χ2=4.16

P<0.05）。11C-MET显像高级别胶质瘤T/NGmax（2.07±0.51）与低级别胶质瘤（1.81±0.52）无显著差异（t=1.302

P=0.205）;18F-FDG显像高级别胶质瘤T/NGmax（1.03±0.30）高于低级别胶质瘤（0.75±0.11

t=3.198

P=0.004）。表明11C-MET PET/CT显像对胶质瘤的诊断

特别是对低级别胶质瘤检出优于18F-FDG

两种显像综合应用有利于胶质瘤的准确分级。

Abstract

In this paper

we investigate the diagnostic value of 11C-methionine(MET) positron emission tomography/computed tomography(PET/CT) for brain gliomas

and compare the results to 18F-fluorodeoxyglucose.Forty-four patients with suspected gliomas were examined with 11C-MET and 18F-FDG PET/CT.18F-FDG and 11C-MET PET/CT images were compared and evaluated by visual and semiquantitative analysis.The accuracy of 11C-MET and 18F-FDG PET/CT for detecting gliomas were 88.6% and 65.9%

respectively.Semiquantitative analysis showed that the 26 gliomas had higher mean ± SD T/NGmax ratio on 11C-MET PET/CT than on 18F-FDG PET/CT(1.95±0.52 vs.0.90±0.27

t=9.101

P<0.001).11C-MET had a higher sensitivity than 18F-FDG(83.3% vs.33.3%

χ2 =4.16

P<0.05) for low-grade gliomas

but it did not differ significantly from 18F-FDG in the sensitivity for high-grade gliomas(100% vs.64.3%

χ2=3.20

P>0.05).The difference was no significant

too

between high-and low-grade gliomas

compared by 11C-MET T/NGmax ratio(2.07±0.51 vs.1.81±0.52

t=1.302

P=0.205).18F-FDG T/NGmax ratio in high-grade gliomas was significantly higher than that in low-grade gliomas(1.03±0.30 vs.0.75±0.11

t=3.198

P=0.004).It is concluded that 11C-MET PET/CT is more accurate than 18F-FDG PET/CT for detecting and delineating gliomas

especially for low-grade gliomas

and it can play a complement role to 18F-FDG in tumor grading.

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DOI：

摘要

Abstract

关键词

Keywords

references

¹¹C-MET和¹⁸F-FDG PET/CT对胶质瘤诊断的价值比较

Comparative PET/CT study with ¹¹C-MET and ¹⁸F-FDG for diagnosing Glioma