The application of biologically active peptides labeled with positron-emitting nuclides has emerged as a useful and interesting field in nuclear medicine. Among a number of positron-emitting nuclides

fluorine-18 appears to be the best candidate for labeling peptides by virtue of its favourable physical and nuclear characteristics. Small peptides are currently the preferred reagents over proteins and antibodies for dignostic imaging

and the 18F-labelled peptides hold enormous clinical potenial . This review presents the recent progress in 18F-labelled small active pep-tides. In addition

different 18F labeling reagents

radiofluorination techniques and pharmacokinetics of 18F-labelled bioactive peptides are described.