This paper reports the labelling method and procedure of Tc-99m-TBI preparation by homogeneous ligand exchanging

This labelled method is easy

with the labelling. rate and radiochemistry purity over 90%. It is convenient to use and popularize in clinic. The clearance of Tc-99m-TBI from the blood in rats was quick

T

1/2

α

was 3.7 min

T

1/2

β was 63 min. Heart/blood ratio was 62.2 and 48.7 in mice at 1 and 2h after giving drug

while heart/liver ratio was 0.85 and 0.81

and heart/lung ratio was 3.7 and 4.0. And dose %/g organ was 11.1±2.6%

13.1±2.1% and 12.8±1.5% in myocardium of mice at 1

2

4h after injection. The Tc-99m-TBI was a new promising myocardial imaging agent.