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上海医科大学
*附属中山医院,上海市心血管研究所
**上海市肿瘤医院
收稿日期:1990-05-24,
纸质出版日期:1990-11-01
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杨一峰, 钱忠豪, 蒋长英, 等. 核素心室造影评价钙通道阻滞剂的即刻心泵功能[J]. 核技术, 1990,13(11):641-644.
Yifeng Yang, Zhonghao Qian, Changying Jiang, et al. Cardiovascular effects of calcium-channel blocker with radionuclide ventriculography[J]. Nuclear techniques, 1990, 13(11): 641-644.
用核素心室造影法评价了心脏病病人口服硝苯啶(NIF
20mg、31例)和地尔硫
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(DIL
60mg、24例)前后血流动力学参数的变化。口服NIF后左心功能显著改善,LVEF自0.56增至0.63(P
<
0.001)
LVEDV增加15ml/m
2
(P
<
0.01)
CO与CI分别增加2.01L/min和1.23L/min/m
2
(
P
均
<
0.001).而口服DIL后左心功能仅轻度改善,LVEF和LVEDV仅分别增加0.03和5ml/m
2
。在陈旧性心肌梗塞病人,无论NIF或DIL均未见心功能的改善。
Hemodynamic parameters were assessed before and 0.5h after the p. o. of 20mg of nifedipine (NIF) in 31 patients and 60 mg of diltiazem (DIL) in 24 patients with radionuclide ventriculography. After oraltherapy
NIF improved the LV pumping fucntion
LVEF increased from 0.56 to 0.63 (P
<
0.001) and LVEDV increased 15 ml/m
2
(
P
<
0.01)
CO and CI increased 2.011/min and 1.231/ (min•m
2
)
respectively
P
<
0.01. But LV pumping function changed slightly after DIL administration
LVEF and LVEDV increased only 0.03 and 5 ml/m
2
respectively
P
>
0.05. In the group of patients with old myocardial infarction
both negative effect were observed.
R. D. Magorien et al . , Circulation , 70 ( 1984 ), 5 : 884 .
T. J. Walley et al . , Clin. Cardiol . , 10 ( 1987 ), 12 : 800 .
J. B. Gill et al . , Am. Heart J. , 113 ( 1987 ), 3 : 700 .
P. F. Cohn et al . , Am. Heart J . , 63 ( 1989 ), 9 : 534 .
P. A. Ludbrook et al . , Circulation , 65 ( 1982 ), 3 : 489 .
R. W. Terry et al . , Am. Heart J , 104 ( 1982 ), 3 : 681 .
N. Brook et al . , Br, Med. J . , 281 ( 1980 ), 15 : 1324 .
X. Z. Prida et al . , J. A. C. C. , 9 ( 1987 ), 2 : 412 .
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