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上海市药品检验所
收稿日期:1988-02-06,
纸质出版日期:1990-03-01
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黄夭森, 蒋红珠, 严伟, 等. 氯化亚铊(201Tl)放射化学纯度测定方法的选择[J]. 核技术, 1990,13(3):172-175.
Tiansen Huans, Hongzhu Jiang, Wei Yan, et al. Selection of methods for determining radiochemical purity of (201Tl) thallous chloride[J]. Nuclear techniques, 1990, 13(3): 172-175.
黄夭森, 蒋红珠, 严伟, 等. 氯化亚铊(201Tl)放射化学纯度测定方法的选择[J]. 核技术, 1990,13(3):172-175. DOI:
Tiansen Huans, Hongzhu Jiang, Wei Yan, et al. Selection of methods for determining radiochemical purity of (201Tl) thallous chloride[J]. Nuclear techniques, 1990, 13(3): 172-175. DOI:
本文以同一批氯化亚铊和氯化铊为供试品,采用醋酸纤维薄膜电泳、纸电泳、预饱和纸层析及非饱和纸层析等不同方法进行比较,发现上述方法均能将供试品中的铊
201
Tl(I)和铊
T1(I)分离。以氯化亚铊(
Tl)作供试品时,测得
Tl(I)数值接近;以氯化铊(
Tl)作供试品时,四种方法测定的
Tl(Ⅱ)的结果很不一致。采用Na
2
HPO
4
:丙铜=10:90为展开剂,预饱和上行纸层析的方法,能有效地测出供试品中
Tl(Ⅱ),误差小,重复性好。为此,推荐上述方法为氯化亚铊(
Tl)放射化学纯度测定方法
Different kinds of chromatographic and electrophoretic methods for determining(
Tl) thallous chloride and thallic chloride were compared in same batch of sample. It was found that mono-valent and tri-valent
Tl ions could be separated by using cellulose acetate-electrophoresis
paper electrophoresis
pre-saturation paper chromatography and non-saturation paper chromatography. Very close results for the amount of mono-valent
Tl were obtained when (
Tl) thallous chloride samples were used for the determination. However
it was not consistent for tri-valent
Tl using the four methods described above. The amount of tri-valent
Tl was determined effectively by the ascending presaturation paper chromatography method using Na
-acetone (10:90) as developing agent. The method
with the advantages of good reproducibility and small error
is there fore recommended for the determination of radiochemical purity of (
Tl) thallous chloride.
Lebowitze et al . , J. Nucl. Med. , 16 ( 1975 ), 151 .
Thallous Chloride 201 Tl Injection: The United States Pharmacopeia, XXI , ( 1986 ).
盐化夕ソウワ( 201 Tl)注射液 , 日本药局方第十一改正 , 1986 年.
A. C. James et al . , J. Lab. Com. Radio.Pharmac. , ?? ( 1977 ), 3 : 437 .
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