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1.浙江医科大学附属第一医院
2.美国南加利福尼亚大学
收稿日期:1987-09-05,
纸质出版日期:1989-04
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陈克云, Epstein A.L., Chen F.M., 等. 131I-Lym-2单克隆抗体实验研究[J]. 核技术, 1989,12(4):249-252.
Keyun Chen, A. L. Epstein, F.M. Chen, et al. Experimental study of 131I-Lym-2 Monoclonal Antibody[J]. Nuclear techniques, 1989, 12(4): 249-252.
不同浓度的
131
I-Lym-2 MoAb与ARH-77和CEM细胞进行结合试验,结果表明:随浓度增大,结合值均升高;实验组裸鼠模型9只获得动力学数据。实验组和对照组注射
131
I-Lym-2 MoAb后144 h解剖,进行生物学分布(%D/g)测定,实验组肿瘤为16.88±12.64,肌肉为0.72±0.56。结果表明,
131
I-131-Lym-2MoAb对临床B细胞淋巴瘤的放射免疫分析、显像有良好的效果。
The binding of
131
I-Lym-2 MoAb to the ARH-77 and CEM cells were 82.80±0.57%and 0.44±0.14% respectively. The daily imaging of the experimental group (9 nude mice) was made to obtain the kinetics data. The experimental and control groups mice were sacrificed at 144 hours after injection for the biodistribution (% Dose/g) data. The uptake of the experimental group was 16.88±12.64 in tumour
and 0.72±0.56 in muscle.
131
I-Lym-2 MoAb was shown to be a potential agent for radioimmunoassay
radioimmunoimaging and radioimmunotherapy of B-cell lymphoma.
A. L. Epstein et al . , The journal of Immunology , 133 ( 1984 ), 2 : 1028 .
Chen KY et al . , Radiolabeled monoclonal antibody for b-cell lymphoma with a new monoclonal antibody . Society of Nuclear Medicine 33rd Annual Meeting , Washington, D.C. 1986 .
陈克云 等 , 中华核医学杂志 , 8 ( 1988 ), 3 : 165 .
陈克云 等 , 中华肿瘤杂志 , 10 ( 1988 ), 6 : 424 .
B. Drewinko et al . , Cancer , 54 ( 1984 ), 1883 .
B. Drewinko et al . , Cancer , 54 ( 1984 ), 1893 .
P. Ralph and B. Drewinko , Cancer , 54 ( 1984 ), 2544 .
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