浓缩铀UO<sub>2</sub>F<sub>2</sub>单次或多次摄入体内的蓄积诱发骨髓细胞突变效应

朱寿彭; 郑斯英; 王崇道; 曹根发; 孙保福

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浓缩铀UO₂F₂单次或多次摄入体内的蓄积诱发骨髓细胞突变效应

更新时间：2022-08-16

- 浓缩铀UO₂F₂单次或多次摄入体内的蓄积诱发骨髓细胞突变效应
- Retention and transference of enriched uranium UO₂F₂ administered once or consecutively and its mutagenic effect on bone marrow cells
- 核技术 1987年10卷第6期
- 作者机构：
  
  苏州医学院
- 作者简介：
- 基金信息：
- DOI：
  中图分类号：
- 收稿日期：1986-07-08，
  
  纸质出版日期：1987-06
- 稿件说明：
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朱寿彭, 郑斯英, 王崇道, 等. 浓缩铀UO₂F₂单次或多次摄入体内的蓄积诱发骨髓细胞突变效应[J]. 核技术, 1987,10(6):53-55,64.

Shoupeng Zhu, Siying Zheng, Chongdao Wang, et al. Retention and transference of enriched uranium UO₂F₂ administered once or consecutively and its mutagenic effect on bone marrow cells[J]. Nuclear techniques, 1987, 10(6): 53-55,64.
朱寿彭, 郑斯英, 王崇道, 等. 浓缩铀UO₂F₂单次或多次摄入体内的蓄积诱发骨髓细胞突变效应[J]. 核技术, 1987,10(6):53-55,64. DOI：

Shoupeng Zhu, Siying Zheng, Chongdao Wang, et al. Retention and transference of enriched uranium UO₂F₂ administered once or consecutively and its mutagenic effect on bone marrow cells[J]. Nuclear techniques, 1987, 10(6): 53-55,64. DOI：

摘要

在生产现场环境中，可溶性浓缩铀UO

有可能通过不同途径单次或多次吸收到机体内

[1]

，为了估价浓缩铀对机体产生的危害程度，有必要阐明UO

被机体摄入后在各主要器官组织的积累和转移动态规律，揭示其呈现的选择性蓄积部位。并探讨该核素诱发对骨髓细胞染色体畸变的损伤效应，为揭示UO

对机体的损伤特点和寻找促排治疗措施提供必要的依据。

Abstract

Retention and transference of enriched uranium UO

were observed after iv once 20 mg/kg and ip 15 mg/kg qd×3d to Wistar male rats. The dynamic retention of radioactivity in the body showed that enriched uranium UO

was chiefly localized in kidney

and then in skeleton and liver. The activity of enriched uranium UO

in skeleton rose steadily while the concentration in kidney and liver droped. It was concluded that the retention peculiarity of enriched uranium was equal to that of natural uranium.

When enriched uranium UO

was accumulated in organism

it caused chromosome aberration on bone marrow cells. Results indicated that the chromosome aberration rates were elevated when the dose of enriched uranium UO

was increased

at the same time the cell division was depressed.

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references

皆川洋二，原子力工业 , 13 , 10 , 45 ( 1976 )。

朱寿彭等，核技术， 4 , 47 ( 1980 )。

朱寿彭等，中国药理学报 , 3 , 3 , 197 ( 1982 )。

朱寿彭，放射毒理学，第一版，北京，原子能出版社， 1983 年，第 310 页。

S. R. Bernard et al. , ORNL -2304 , ( 1957 ).

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浓缩铀UO2F2单次或多次摄入体内的蓄积诱发骨髓细胞突变效应

Retention and transference of enriched uranium UO2F2 administered once or consecutively and its mutagenic effect on bone marrow cells

DOI：

摘要

Abstract

关键词

Keywords

references

浓缩铀UO₂F₂单次或多次摄入体内的蓄积诱发骨髓细胞突变效应

Retention and transference of enriched uranium UO₂F₂ administered once or consecutively and its mutagenic effect on bone marrow cells