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山东省医学科学院
收稿日期:1986-04-25,
纸质出版日期:1987-04
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史纪兰, 商希梅, 李志荣. 辐照药用淀粉的毒性研究[J]. 核技术, 1987,10(4):27-31,62,63.
Jilan Shi, Ximei Shang, Zhirong Li. Study on toxcity of irradiated medicinal starch[J]. Nuclear techniques, 1987, 10(4): 27-31,62,63.
为确保人们食用的安全,对用
60
Co-γ射线辐照5kGy的药用淀粉的毒性进行研究。通过90只Wistar大鼠的90天喂养试验及短期致突试验观察,证明辐照淀粉对大白鼠的生长、发育、食物利用率、血象、肝功能均无明显影响,亦未见骨髓嗜多染红细胞微核率、染色体畸变率及多倍体增加,证明无遗传毒性反应。Ames试验也说明辐照淀粉不诱发DNA中碱基对的置换型和移码型突变。病理改变及脏器系数的变化与对照组无显著性差异,未显示出对脏器的毒性作用。经上述实验证明食用辐照淀粉是安全的。
Toxcity test of a medicinal starch irradiated with a dose of 5kGy by
60
Co γ source has been carried out with feeding test for 90 days and short-term test for mutagenicity. The results showed non-significant effects on the growth
feed availability rate
blood picture and liver function in the rats fed with irradiated starch. The increase of MNPCE in bone marrow
chromosomal aberration rate and polyploid were not observed in the tests. All results were proved that non-genotoxic effects was occured.
Ames test showed that both of the base pair transversion and frameshift mutant in DNA was not induced by irradiated starch. There was no statistical significance in both. pathologic changes and the organic coefficient between the testing group and contracts-The safety of eating irradiated starchmay be justified by all the tests above.
上海第一医学院 等 , 食品毒理 , 人民卫生出版社 , 1978年 , 第10、29页 。
潘媞华 等 , 辐照花生仁动物喂养试验 , 青岛医学院科研资料 , 1984年 。
B. N. Ames , Mut. Res ., 31 , 347 ( 1975 ).
M. Macon . and B. N. Ames , Mut. Res ., 113 , 173 ( 1985 ).
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