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上海医科大学附属中山医院
收稿日期:1986-03-31,
纸质出版日期:1987-02
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方瑞英, 赵惠扬, 钱峰, 等. 99m锝标记尿激酶活力测定[J]. 核技术, 1987,10(2):54-56,F3.
Reiying Fang, Huiyang Zhao, Feng Qian, et al. Measurement of the activity technetium-99m labelled urokinase[J]. Nuclear techniques, 1987, 10(2): 54-56,F3.
99m
Tc标记尿激酶(血栓显像剂),国内未见报道,我们于1984年研制成功,并应用于临床,得到较为满意效果。但尿激酶经过放射性核素标记以后是否仍然保持一定的生物活力,必须经过严格的活力测定才能判断。本文报道两种尿激酶活力测定方法:(1)气泡法,它是用时间差来进行计算的,即气泡上升时间减去放入水浴时间,将测试结果查标准曲线即得标记以后尿激酶效价单位。(2)纤维蛋白平板测定法,溶圈大小与尿激酶活力呈对数直线关系,在标准曲线上查出
99m
Tc标记尿激酶效价单位。
Technetium-99m labelled urokinase (a kind of embolus imaging agent) has been successfully applied to the clinical work in our department. Apart from the biological activity
this paper reported two methods for the measurement of the activity of the
99m
Tc-urokinase. One was air bubble method
another was fibrinous stereotyped method. Both of them appeared some advantages of a high-speed
simple
convenient
reliable and easy to practice.
方瑞英 等 , 核技术 , 6 , 43 ( 1984 )。
赵惠扬 等 , 99m Tc标记尿激酶血栓显像剂(电解法)初步临床应用 , 待发表 。
G. Murano et al ., Blood , 55 , 430 ( 1980 ).
P. Wallen et al., proceedings of serono symposia , vol. 9 , Academic Press Inc. , New York , 1977 , p. 91 .
ibid, p. 69 .
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