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苏州医学院
收稿日期:1981-04-24,
纸质出版日期:1983-02
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朱寿彭, 何广仁. 用放射自显影术对比99mTc两种骨扫描剂的体内定位特性[J]. 核技术, 1983,06(1):56-57,78.
Shoupeng Zhu, Guangren He. Comparing the localizing characteristic of two bone imaging agents by autoradiography[J]. Nuclear techniques, 1983, 06(1): 56-57,78.
应用各种亲骨性放射性核素进行骨病变的研究时,目前认为骨扫描具有较早的诊断价值
[1]
。对骨肿瘤的诊断定位,多使用
99m
Tc-焦磷酸盐和
99m
Tc-亚甲基二磷酸盐
[2]
。由于
99m
Tc的物理半衰期只有6.02小时,主要发射能量为140~142keV的低能γ射线,因而很适合于进行高速放射自显影的操作
[3
4]
。我们用放射自显影法对上述两种骨扫描剂进行了体内定位特性的对比研究。
The autoradiographic study show that
99m
Tc-PYP was retained more than
99m
Tc-MDP in the blood stream. This was attributed to the rapid diffusion of the
99m
Tc-PYP into the circulating blood cell. The autoradiography of bone marrow smear shew that
99m
Tc-PYP localized predominately in the blast cell and freezing microautoradiography demonstrated that
99m
Tc-MDP deposited more in bone tissue than
99m
Tc-PYP. All of these might explain why
99m
Tc-MDP could produced good image shortly after administration.
G. L. Schall , J. Surg. Oncol ., 3 , 673 ( 1971 ).
T. G. Rudd , J. Nucl. Med ., 18 , 872 ( 1977 ).
朱寿彭 和 江骥 , 中国药理学报 , 2 , 1 , 64 ( 1981 ).
朱寿彭 , 中国药理学报 , 2 , 3 , 197 ( 1981 ).
朱寿彭 和 江骥 , 放射医学与防护 , 4 , 37 ( 1980 ).
A. W. Rogers ed. , Techniques of autoradiography , 2nd ed . Amsterdam , Elsevier , 1973 , p. 44 .
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