Comparison of <italic style="font-style: italic">γ-γ</italic> perturbed angular correlation of serums of healthy and cancer rats

Ni Xin-bo; Wang Yong-xian; Sun Qi-xun; Yang Jing-qing; Yin Duan-zhi; Lin Jun-ying; Hu Miao-jun; Si Xi-chang; Wang Yong-chuan; Ji Qi-mei; Ma Wei-duo; Xie De-feng

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Comparison of γ-γ perturbed angular correlation of serums of healthy and cancer rats

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- Comparison of γ-γ perturbed angular correlation of serums of healthy and cancer rats
- 正常与患癌小鼠血清γ-γ扰动角关联谱的比较研究
- Nuclear Techniques 1981年04卷第2期
- 作者机构：
  
  Shanghai Institute of Nuclear Research, Academia Sinica
- 作者简介：
- 基金信息：
- DOI：
  中图分类号：
- 收稿日期：1979-11-27，
  
  纸质出版日期：1981-04
- 稿件说明：
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Ni Xin-bo, Wang Yong-xian, Sun Qi-xun, 等. Comparison of γ-γ perturbed angular correlation of serums of healthy and cancer rats[J]. Nuclear Techniques, 1981,04(2):39-41.

新伯倪, 勇先汪, 祺薰孙, et al. 正常与患癌小鼠血清γ-γ扰动角关联谱的比较研究[J]. 核技术, 1981, 04(2): 39-41.
Ni Xin-bo, Wang Yong-xian, Sun Qi-xun, 等. Comparison of γ-γ perturbed angular correlation of serums of healthy and cancer rats[J]. Nuclear Techniques, 1981,04(2):39-41. DOI：

新伯倪, 勇先汪, 祺薰孙, et al. 正常与患癌小鼠血清γ-γ扰动角关联谱的比较研究[J]. 核技术, 1981, 04(2): 39-41. DOI：

摘要

Abstract

扰动角关联方法1968年首次应用于生物学研究

[1]

，现更多地用来研究生物大分子构型的变化、探测液态分子的旋转关联时间

[2]

、测定金属离子结合生物大分子的离解常数

[3]

及结合位置等

[4～6]

，为生物学研究提供了有用的数据，并正在发展成为一种生物物理学的新方法，将在分子生物学及药物代谢动力学中显示其优越性。

In this work

the average perturbed angular correlation integral attenuation factor G

were measured using time—integral perturbed angular correlation method

0.1205 ± 0.0098 for serum of cancer LCR rats

0.1853±0.0324 for normal LCR rats. The difference between these two factors is obvious (P

0.01) . Because the

111

In is bound to transferrin molecule in the serum

it seems that the equivalent radius of transferrin molecule of cancer LCR rats is smaller than that of normal LCR rats and the molecular conformations are different with each other.

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references

T. K. Liepert et al ., Nature , 220 , 907 ( 1968 ).

D. A. Shirley , J. Chem. Phys. , 53 , 465 ( 1970 ).

K. S. R. Sastry et al ., Hyperfine Interactions , 4 , 891 ( 1978 ).

R. Bauer et al ., Phys. Rev. Lett. , 32 , 340 ( 1974 ).

R. Baure et al ., Biochemistry , 15 , 334 ( 1976 ).

C. F. Meares et al ., Proc. Nat. Acad. Sci. USA , 64 , 1155 ( 1969 ).

A. G. Marshall and C. F. Meares , J. Chem. Phys. , 56 , 1226 ( 1972 ).

D. Wallach , J. Chem. Phys. , 47 , 5258 ( 1967 ).

扰动角关联组，核技术， 1 , 32 ( 1979 ).

D. D. Zdankiewicz et al ., Clin. Chim. , 22 , 1361 ( 1976 ).

P. W. Martin and K. Skov , Journal of Nuclear Medicine , 19 , 1171 ( 1978 ).

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Comparison of γ-γ perturbed angular correlation of serums of healthy and cancer rats

正常与患癌小鼠血清γ-γ扰动角关联谱的比较研究

DOI：

摘要

Abstract

关键词

Keywords

references