最新刊期
      卷 0 ， 期 0 ， 2020
      • LIU Chenglin1,2 YAN Xiaohui1 ZHANG Xinyi1,3 ZHU Peiping4 HUANG Wanxia4 YUAN Qingxi4 1
        Issue 12, (2006)
        摘要：For discussing the relation between the contrast of X-ray diffraction enhanced imaging (DEI) and the energy of X-rays, the massive samples of breast tissue including normal and cancerous were studied with the DEI method using the hard X-rays from 4W1A beamline at the Beijing Synchrotron Radiation Facility (BSRF). The results show that the contrasts of the peak-position image or apparent absorption image keep unchanged when different X-ray energies are used. The contrast of refraction image trends to be weakened when the X-ray energy is increased. As a result, it seems the DEI method is fit to image objects made of light elements.  
        关键词：X-ray diffraction enhanced imaging;Contrast;X-ray energy;Synchrotron radiation;Breast tissue   
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        发布时间：2021-03-12
      • LIU Chenglin1,2 YAN Xiaohui1 ZHANG Xinyi1,3 ZHU Peiping4 HUANG Wanxia4 YUAN Qingxi4 1
        Issue 12, (2006)
        摘要：On the basis of the DEI’s principle, a simple experimental model is used to analyze the process and character of DEI. The peak-position image, which is recorded at the peak of the rocking curve, has higher contrast than the absorption images and can show also micro-structures inside the samples. The apparent absorption image is similar to the conventional X-ray image, while the refraction image is extraordinarily sensitive to the change of the refractive index of the sample, and can clearly display edges of organic objects having different refractive indexes. The refraction image recorded in the middle position of rocking curve has better quality than that in the toe position. Furthermore, the background of the analyzer crystal affects the quality of the DEI, but does not affect the refraction image. Therefore, the refraction image has very good reliability in distinguishing normal or disease tissues, as well as for industrial inspection.  
        关键词：Edge effect;Background;Diffraction enhanced imaging(DEI);Synchrotron radiation   
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        发布时间：2021-03-12
      • WU Maoyuan ZHAO Guobi ZHU Yi XIA Shaojian YE Kairong
        Issue 12, (2006)
        摘要：This paper reports the design of the first extracting mirror of SR (synchrotron radiation) monitor system in SSRF (Shanghai SR Facility). The design aims at extracting the visible light from synchrotron radiation without distortion. The difficulty is that the high power X-ray of SR heats and damages the extracting facility, then it is transfigured to affect the wavefront and amplitude of the visible light. After the analysis of SR power spectrum and the heat transfiguration based on ANSYS program, we designed a beryllium mirror with a water-cooling system to reflect visible light and transmit X-ray to satisfy requirements of design.  
        关键词：SR (synchrotron radiation);SSRF (Shanghai SR Facility);Beam measurement;SRM (SR monitor);Beryllium mirror;Xop program;ANSYS program   
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        发布时间：2021-03-12
      • CHEN Yonglin JIANG Dikui ZHU Xikai GUO Panlin XU Xiangyi WANG Naxiu
        Issue 12, (2006)
        摘要：The drift tube assembly provides the axial trap for ions in an electron beam ion trap(EBIT). It works under low temperature, strong magnetic field, ultra high vacuum and high electric potential, which leads to high requirements for its design. In this paper, the design of the potential trap, the structure of the assembly, the procedures for solving engineering problems, and the tests about low-temperature and high-voltage operation of the assembly are introduced. This work plays an important role in the development of the Shanghai EBIT, which can be operated stably at present with an electron beam of 100kV/110mA.  
        关键词：Shanghai EBIT facility;Drift tubes assembly;Highly charged ions   
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        发布时间：2021-03-12
      • LIU Lin1,3 ZHOU Weijian1,3 SONG Shaohua1,2 ZENG Yi1,2 CHEN Maobai1 1
        Issue 12, (2006)
        摘要：It is well demanded to improve the precision of 14C dating and the sensitivity of long lived radioisotopes such as 10Be and 26Al in the AMS field. A set of new dual-purpose injection system based on HVEE model 4130 AMS facility is proposed by Xi’an AMS Center, which can operate in both simultaneous and sequential modes on one set of the system by using the Wien filter. It obviously simplifies the layout as compared with the existing dual-injector and dual high energy beam line system. The calculation shows that the new dual injection system will increase the species of radionuclides which can be analyzed. Keeping the high precision of model 4130 AMS for radiocarbon dating the new system can achieve the ultra-sensitivity measurements for the nuclides such as 10Be and 26Al.  
        关键词：AMS;Dual-purpose injection system;Wien filter   
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        发布时间：2021-03-12
      • TANG Bin1,2 LIU Ling2 ZHOU Shumin2 ZHOU Rongsheng1 1
        Issue 12, (2006)
        摘要：The paper discusses the gamma-ray spectrum interpretation technology on nuclear logging. The principles of familiar quantitative interpretation methods, including the average content method and the traditional spectrum striping method, are introduced, and their limitation of determining the contents of radioactive elements on unsaturated ledges (where radioactive elements distribute unevenly) is presented. On the basis of the intensity gamma-logging quantitative interpretation technology by using the deconvolution method, a new quantitative interpretation method of separating radioactive elements is presented for interpreting the gamma spectrum logging. This is a point-by-point spectrum striping deconvolution technology which can give the logging data a quantitative interpretation.  
        关键词：Average content interpretation method;Traditional spectrum striping technology;Point-by-point spectrum striping technology;Deconvolution quantitative interpretation;Characteristic coefficient α   
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        发布时间：2021-03-12
      • LIN Xiufeng YU Huixin TAN Cheng ZHANG Li CHEN Bo ZHANG Rongjun XU Xijie CAO Guoxian
        Issue 12, (2006)
        摘要：To investigate the preparation of radioiodinated salidroside and its cell uptake in SH-SY5Y and its biodis-tribution in mice, salidroside was labeled with 131I using the chloramine-T method and the radiolabeled compound was characterized by polyamide TLC, in which the substratum of Vtrichoromethane: Vmethanol: Vacetone: Vwater=6:3:1:1 was used as the developing agent. The uptake of 131I-salidroside in human neuroblast cells(SH-SY5Y) and mammary can-cer cells(MCF-7) was then measured and the biodistribution studies were carried out in KM mice. At different time(5, 10, 30, 60, 120, and 240 min) after radiopharmaceutical i.v. administration (1.85MBq 131I-salidroside /mouse), the animals were sacrificed (n=5 animals for each time). Blood and the interested tissues samples were collected, washed, weighted and counted. The percent injected dose per gram (%ID/g) was calculated for each sample. The labeling yield of 131I-salidroside was 98% and its RCPs were 98.5%, 97.3%, and 97.1% after 1, 4 and 20 days, respectively. In SH-SY5Y, 131I-salidroside uptake kept at a low level of around 0.035% from 0.5 to 4h, while in MCF-7 a slightly higher uptake of 0.1% was reached. Biodistribution in mice demonstrated that 131I-salidroside was metabolized mainly in liver and rapid elimination through kidney, in which the % ID/g were 7.71% and 11.31% at 5 min, 0.36% and 0.3% at 4h, respectively. Rapid clearance was also found in blood, 6.43% at 5 min and decreased to 0.35% at 4h. A little distribution appeared in brain with slower clearance, the %ID/g were 0.27% at 5 min and 0.11% at 4h. In heart, lung, spleen, muscle, bone, and intestines, there were little distributions. It is concluded that labeling yield of 131I-salidroside was high and the radioiodinated salidroside was stable, but its uptake in neuroblast was little.  
        关键词：Salidroside;Radioiodine-labeling;Biodistribution;Cellular uptake   
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        发布时间：2021-03-12
      • CHENG Dengfeng YIN Duanzhi WANG Mingwei LI Gucai ZHOU Wei WANG Yongxian
        Issue 12, (2006)
        摘要：We have synthesized 18F–labeled prosthetic group, N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) for fluorine-18 labeling peptides and proteins. [18F]SFB seems to be the most suitable 18F-labeling agent because of its higher labeling yield and better stability of the conjugates in vivo. Labeling prosthetic group, triflate salt of ethyl p-trimethylammonium benzoate, was synthesized first, then the radio-synthesis with three steps was carried out, and the first step about 18F –labeling was optimized. After purifying through Sep-Pak C18 cartridge, [18F]SFB was produced with the decay-corrected radiochemical yield of 50% within 1 hour.The radiochemical purity was more than 98% by using radio-TLC and HPLC.  
        关键词：Fluorine-18;N-succinimidyl 4-[18F]fluorobenzoate;Radio-synthesis   
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        发布时间：2021-03-12
      • XIA Jiaoyun1,2 WANG Yongxian1 LI Shiqiang1 YU Junfeng1 TANG Lin1 YIN Duanzhi1 1
        Issue 12, (2006)
        摘要：The organometallic precursor fac-[188Re (CO)3(H2O)3]+ is reacted with three novel tridentate ligands (L1NH2, L2H, L3NH2) and the properties of their 188Re complexes in vivo have been evaluated. The results of labeling condition experiments show that a radiochemical purity higher than 90% can be obtained within 60 min by the reaction of fac-[188Re (CO)3]+ core in the condition of pH=7.4 with a very small amount (10-5 mol/L) of these three new ligands. At the same time, three Re-tricarbonyl complexes of three ligands were also synthesized as reference samples, which were used to confirm the structures of 188 Re-tricarbonyl complexes of three ligands by HPLC. The stability experiments in vitro demonstrate that fac-[188Re(CO)3L1NH2]+, fac-[188Re(CO)3L2H] and fac-[188Re(CO)3L3NH2] do not decompose within 24 h (37 ℃, in new born small calf serum). Histidine and cysteine challenge experiments (37℃, PBS, pH=7.4) show that fac-[188Re(CO)3L1NH2]+ and fac-[188Re(CO)3L2H] have higher stabilities than fac-[188Re(CO)3L3NH2], which indicates that the combination ability of –OH in –COOH with fac-[188Re(CO)3L2H] core was higher than that of –N in pyridine. It is also indicated that three novel tridentate ligands (L1NH2, L2H, L3NH2) are better bifunctional chelating agents for the labeling by the precursor fac-[188Re (CO)3(H2O)3]+.  
        关键词：Rhenium-188;Tricarbonyl complexes;Bifunctional chelating agents   
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        发布时间：2021-03-12
      • SUN Liang LI Junli CHENG Jianping
        Issue 12, (2006)
        摘要：In this paper, a mixed algorithm based on genetic algorithm(GA) and Gauss-Newton algorithm was presented and applied in analysis of biokinetic data of radiopharmaceuticals through an example. A special software was programmed for data fitting. The results showed that the practically mixed algorithm was better than simple GA or Gauss-Newton algorithm.  
        关键词：Genetic algorithm;Gauss-Newton algorithm;Radiopharmaceuticals;Biokinetics;Data analysis   
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        发布时间：2021-03-12
      • XIONG Liangping XU Yunshu XIA Xiulong HUANG Wei XIONG Jie GAO Xiaoling
        Issue 12, (2006)
        摘要：Polycarbosilane (PCS) ceramic precursor fibers were irradiated by a nuclear reactor under inert atmosphere. The chemical structure of the irradiated products and the effect of neutron fluence on curing were studied, and the reaction mechanism was presumed. Results showed that the infusibilization of PCS fibers were achieved when irradiated at the neutron fluence of 2.6×1017cm-2 under N2 atmosphere, and the gel content and ceramic yield were 80% and 94.3%, respectively. The sintered products were still fibrous. The content of oxygen introduced in this process was very low. Bridge structure of Si―CH2―Si was formed by the rupture of Si-H bonds and succeeding radiation cross-linking.  
        关键词：Polycarbosilane precursor fiber;Curing;Nuclear reactor;Irradiation   
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        发布时间：2021-03-12
      • LIU Suping HAO Fanhua GONG Jian WU Huailong HU Guangchun Hu Yongbo
        Issue 12, (2006)
        摘要：A long-term detection of the 871 keV gamma-ray emitted from two PuO2 samples (100 g recovered powder and 8 g pure powder) has been conducted with a high resolution HPGe spectrometer in a lead-shielded chamber. An on-site detection of the 871 keV gamma-ray emitted from 200 g recovered PuO2 powder has also been performed. Although the 871 keV peak can be observed in all 3 samples, other characteristic gamma-rays related to the existence of oxygen are not seen. The 871 keV peak is absent in spectra acquired from metal plutonium samples, which can answer whether the plutonium material in a sealed container is metal plutonium or plutonium oxide, i.e. the 871 keV gamma-ray can be an evidence for the absence of metal plutonium. The 871 keV peak is strong in the spectrum of 200 g recovered PuO2 sample. A software of plutonium abundance and age analysis developed by ourselves can identify the 871 keV peak from a spectrum of 10 min. If the system is appropriately improved, it can be used to detect attribute of plutonium oxide through identifying 871 keV gamma-ray peak.  
        关键词：Plutonium oxide attribute;Sealed container;Metal plutonium;Plutonium oxide;Verification   
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        发布时间：2021-03-12
      • SU Qiong1 DIAO Lijun2 LI Guiqun2 CHENG Jianping1 1
        Issue 12, (2006)
        摘要：A remarkable systemic error which was unknown in past long time has been indicated. The error appears in the calibration methods of determining activity of 238U is used with γ-spectrometer with high resolution. When the γ-ray of 92.6 keV as the characteristic radiation from 238U is used to determine the activity of 238U in natural environment samples, the disturbing radiation produced by external excitation (or called outer sourcing X-ray radiation) is the main problem. Because the X-ray intensity is changed with many indefinite factors, it is advised that the calibration methods should be put away. As the influence of the systemic errors has been left in some past research papers, the authors suggest that the data from those papers should be cited carefully and if possible the data ought to be re-determined.  
        关键词：Systemic error;Efficiency calibration;X-ray;Disturbing radiation;γ spectrometer;(238)~U   
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        发布时间：2021-03-12
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