Analysis and optimization of production conditions for <sup>18</sup>F production using a medical cyclotron

Feng WANG; Jianhua YANG; Qing XIE; Shizhen ZHAI; Zhi YANG

doi:10.11889/j.0253-3219.2018.hjs.41.020301

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Analysis and optimization of production conditions for ¹⁸F production using a medical cyclotron

NUCLEAR CHEMISTRY, RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE | 更新时间：2021-05-19

- Analysis and optimization of production conditions for ¹⁸F production using a medical cyclotron
- NUCLEAR TECHNIQUES Vol. 41, Issue 2, Article number: 020301(2018)
- 作者机构：
  
  北京大学肿瘤医院暨北京市肿瘤防治研究所核医学科恶性肿瘤发病机制及转化研究教育部重点实验室北京 100036
- 作者简介：
- 基金信息：
  
  National Natural Science Foundation of China;National Natural Science Foundation of China;Beijing Natural Science Foundation
- DOI：10.11889/j.0253-3219.2018.hjs.41.020301
  CLC： TL99
- Received：20 July 2017，
  
  Revised：15 November 2017，
  
  Published：10 February 2018
- 稿件说明：
移动端阅览
Feng WANG, Jianhua YANG, Qing XIE, et al. Analysis and optimization of production conditions for ¹⁸F production using a medical cyclotron[J]. Nuclear techniques, 2018, 41(2): 020301
DOI：

Feng WANG, Jianhua YANG, Qing XIE, et al. Analysis and optimization of production conditions for ¹⁸F production using a medical cyclotron[J]. Nuclear techniques, 2018, 41(2): 020301 DOI： 10.11889/j.0253-3219.2018.hjs.41.020301.

摘要

分析医用回旋加速器正电子核素

F的照射条件和轰击参数对生产的影响，优化生产条件并给出最佳的轰击参数以期获得高效的生产产额。使用Origin 9.0软件绘制核素

F产量随不同质子束流强度和轰击时间的变化趋势曲线，以蒙特卡罗方法建立回旋加速器质子辐照靶室模型，分析不同质子能量、Havar膜和靶水厚度等对核素

F产量的影响，并给出

F生产最佳的束流强度、轰击时间和质子能量等生产参数。回旋加速器运行期间束流应充分聚焦于照射靶室中心位置，最大化的利用束流以引发足够多的核反应；根据质子束流的能量选择合适的Havar膜和靶水厚度，20 MeV质子束流轰击生产正电子核素

F的靶室系统使用Havar膜总计厚度60μm，靶水厚度3 mm，可获得最佳

F产量。总体而言，

F的产量随束流强度而增大，轰击时间越长

F产量越大，但随着轰击时间的延长增长趋势变缓，轰击时间建议60 min左右。正电子核素

F的生产需要选择合适的Havar膜和靶水厚度（当质子能量为20 MeV时，推荐Havar厚度60 μm，靶水厚度3 mm），轰击时间建议60 min左右，开机启动稳定一段时间后再开始照射。

Abstract

Background

Positron emission tomography/computed tomography (PET/CT) is a routine diagnostic method of particular importance for treatment evaluation and management in oncology. It is very important for PET/CT diagnosis to produce good quality and quantity positron nuclides using medical cyclotron.

Purpose

The effect of irradiation conditions and bombardment parameters on positron nuclide

F production was analyzed to acquire the optimized production conditions and optimum bombardment parameters.

Methods

Origin 9.0 software was used to analyze the change of

F yield with different proton beam current and bombardment time. Monte Carlo method was applied to establish the target chamber model of proton irradiation

and the proton energy

thicknesses of Havar foils and the

O water were analyzed to obtain the optimum conditions of beam current

bombardment time and the proton energy

etc.

Results

Proton beam should thoroughly irradiate on target chamber center to make the best of beam current for triggering as much as nuclear reaction. When 20-MeV proton beam was used to produce

the thicknesses of Havar foil and the target water were recommended to be 60 μm and 3 mm

respectively. Usually

the yield of

F increases with the beam current. The longer the bombardment time was

the higher the yield of

F. But with bombardment time increased

the trend of yield became slower. The bombardment time was suggested approximately 60 min.

Conclusion

It is necessary to select the appropriate thicknesses of Havar foil and the

O water for positron radionuclide

F production (this paper shows that the thicknesses of Havar foil and the

O water should be 60 μm and 3 mm when the proton energy is 20 MeV). The irradiation time was suggested approximate 60min to obtain high yield of

F. Furthermore

irradiation should be started after the cyclotron run for a period of time for stabilization.

关键词

Keywords

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Analysis and optimization of production conditions for 18F production using a medical cyclotron

DOI：10.11889/j.0253-3219.2018.hjs.41.020301

摘要

Abstract

关键词

Keywords

references

Analysis and optimization of production conditions for ¹⁸F production using a medical cyclotron