Autophagy-based mechanistic understanding of healthcare science

Chenglie LIN; Jiang LI; Yi ZHOU; Yanhong SUN; Lihua WANG; Jun HU; Chunhai FAN

doi:10.11889/j.0253-3219.2017.hjs.40.020501

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Autophagy-based mechanistic understanding of healthcare science

NUCLEAR CHEMISTRY, RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE | 更新时间：2021-05-19

- Autophagy-based mechanistic understanding of healthcare science
  封面论文
- NUCLEAR TECHNIQUES Vol. 40, Issue 2, Article number: 020301(2017)
- 作者机构：
  
  1.中国科学院上海应用物理研究所微观界面物理与探测重点实验室物理生物学研究室上海同步辐射光源生物成像中心上海 201800
  2.成都中医药大学基础医学院成都 611137
- 作者简介：
- 基金信息：
  
  National Natural Science Foundation of China;National Natural Science Foundation of China
- DOI：10.11889/j.0253-3219.2017.hjs.40.020501
  CLC： Q274
- Received：28 October 2016，
  
  Revised：14 November 2016，
  
  Published：10 February 2017
- 稿件说明：
移动端阅览
Chenglie LIN, Jiang LI, Yi ZHOU, et al. Autophagy-based mechanistic understanding of healthcare science[J]. Nuclear techniques, 2017, 40(2): 020301
DOI：

Chenglie LIN, Jiang LI, Yi ZHOU, et al. Autophagy-based mechanistic understanding of healthcare science[J]. Nuclear techniques, 2017, 40(2): 020301 DOI： 10.11889/j.0253-3219.2017.hjs.40.020501.

摘要

自噬（autophagy）是细胞对自身组件进行降解与回收的自然过程，与人类健康高度相关。很多疾病都伴随着自噬的异常。本文回顾了国内外近年来在自噬与健康关系领域的研究，包括自噬与癌症、神经退行性疾病等疾病的关系。并且回顾了对人体健康有明显影响的电离辐射、体育锻炼、针灸、按摩等物理刺激对细胞自噬的调控作用，从自噬的角度对这些作用的分子机制进行了讨论。最后，对于自噬调控在未来的医疗保健中的潜在价值进行了展望。

Abstract

Background:

Autophagy is a natural process in cells for self-digestion of intracellular elements

which is highly related to human health.

Purpose:

To better understand the relationship between autophagy and health issues like cancer

neurodegeneration and aging

we reviewed recent studies on this topic in this paper. We also reviewed some physical stimulations that have effects on health while have been verified capable to induce autophagy

including ionic radiation

physical exercise

acupuncture and massage.

Results & Conclusion:

We discussed the molecular mechanisms of their effects from the point of autophagy

and looked to the future of healthcare where the regulation of autophagy may be heavily involved.

关键词

Keywords

references

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