Fully automated synthesis of <sup>18</sup>F-FDG by acidic hydrolysis on domestic module

Haifeng LI; Xiaojun ZHANG; Yungang LI; Jinming ZHANG

doi:10.11889/j.0253-3219.2016.hjs.39.080301

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Fully automated synthesis of ¹⁸F-FDG by acidic hydrolysis on domestic module

更新时间：2021-05-24

- Fully automated synthesis of ¹⁸F-FDG by acidic hydrolysis on domestic module
- NUCLEAR TECHNIQUES Vol. 39, Issue 8, Article number: 080301(2016)
- 作者机构：
  
  1.江西省肿瘤医院核医学科南昌 330029
  2.中国人民解放军总医院核医学科北京 100853
- 作者简介：
- 基金信息：
  
  Supported by the Enhancing Program of Military Hospital Prepared Medicine
- DOI：10.11889/j.0253-3219.2016.hjs.39.080301
  CLC： TL92+3
- Received：03 April 2016，
  
  Revised：29 April 2016，
  
  Published：2016-08
- 稿件说明：
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Haifeng LI, Xiaojun ZHANG, Yungang LI, et al. Fully automated synthesis of ¹⁸F-FDG by acidic hydrolysis on domestic module[J]. Nuclear techniques, 2016, 39(8): 080301
DOI：

Haifeng LI, Xiaojun ZHANG, Yungang LI, et al. Fully automated synthesis of ¹⁸F-FDG by acidic hydrolysis on domestic module[J]. Nuclear techniques, 2016, 39(8): 080301 DOI： 10.11889/j.0253-3219.2016.hjs.39.080301.

摘要

FDG

F-脱氧葡萄糖（

F-FDG）合成模块一般仅能采用一种工艺进行生产，改变工艺条件会对产品质量造成影响，本文旨在解决此问题，同时优化生产工艺。本研究对国产碱水解FDG合成模块进行改进，省去自动加碱装置及在柱水解部件。通过研究亲核反应时间、盐酸量、水解时间及残留溶剂等影响因素，寻求酸水解合成

F-FDG最优化的合成工艺。从淋洗18F-离子至终产品

F-FDG的总合成时间为27 min，合成效率为60.27%±2.29%（

=37，未校正效率），产品放化纯度大于98%，产量（29.15±3.09）GBq（

=37）。改进的合成工艺实现了自动化、稳定合成

F-FDG，产品满足临床需求，实现了两种不同工艺在同一模块上制备

F-FDG。

Abstract

Background:

The FDG

F-fluorodeoxyglucose (

F-FDG) synthesis module was obtained by one process of production generally. The adjusting of synthetic technology would have a significant influence on the quality of product.

Purpose:

In order to solve the problem and optimize the production process

in this paper

the domestic FDG synthesis module has been improved.

Methods:

The domestic FDG synthesis module of basic hydrolysis was optimized by removing the components of automatic alkali-adding and on-column hydrolysis. The influencing factors of synthesis process were discussed

including the time of nucleophilic reaction

the amount of HCl

the hydrolysis time and the residual solvents.

Results:

It took 27 min from

F-to final product of

F-FDG

and a radiochemical yield of 60.27%±2.29% (

=37

End of Synthesis (EOS)) was obtained. The radiochemical purity of

F-FDG was higher than 98% and the radioactivity was (29.15±3.09) GBq (

=37).

Conclusion:

The synthetic process was reliable and automated

and the product was suitable for clinical use. Finally

two different processes were used for synthesizing

F-FDG on the same module.

关键词

Keywords

references

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Fully automated synthesis of 18F-FDG by acidic hydrolysis on domestic module

DOI：10.11889/j.0253-3219.2016.hjs.39.080301

摘要

Abstract

关键词

Keywords

references

Fully automated synthesis of ¹⁸F-FDG by acidic hydrolysis on domestic module