Fe3O4 nanoparticle-protein interactions and their bioeffects

XIA Kai; KONG Huating; CUI Zhifen; ZHANG Yu; PAN Liang; ZHU Ying

doi:10.11889/j.0253-3219.2015.hjs.38.050501

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Fe3O4 nanoparticle-protein interactions and their bioeffects

更新时间：2021-03-03

- Fe3O4 nanoparticle-protein interactions and their bioeffects
- NUCLEAR TECHNIQUES Vol. 38, Issue 5, Article number: 050501(2015)
- 作者机构：
  
  1. 中国科学院上海应用物理研究所物理生物学室生物成像中心，上海同步辐射光源,上海,201800
  2. 中国科学院大学,北京,100049
- 作者简介：
- 基金信息：
- DOI：10.11889/j.0253-3219.2015.hjs.38.050501
  CLC：
- Published：08 May 2015
- 稿件说明：
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XIA Kai, KONG Huating, CUI Zhifen, et al. Fe3O4 nanoparticle-protein interactions and their bioeffects[J]. Nuclear techniques, 2015, 38(5): 050501
DOI：

XIA Kai, KONG Huating, CUI Zhifen, et al. Fe3O4 nanoparticle-protein interactions and their bioeffects[J]. Nuclear techniques, 2015, 38(5): 050501 DOI： 10.11889/j.0253-3219.2015.hjs.38.050501.

摘要

研究了在生物医学领域广泛应用的Fe3O4纳米颗粒与多种蛋白（包括白蛋白、纤维蛋白和免疫球蛋白等）的相互作用及其生物学效应，结果发现Fe3O4纳米颗粒与蛋白的相互作用存在蛋白种类选择性，对蛋白的吸附能力由强到弱依次为纤维蛋白>免疫球蛋白>白蛋白。形成的Fe3O4纳米颗粒-蛋白复合物有效地降低了纳米颗粒的细胞毒性。

Abstract

Background: Fe3O4 nanoparticles have wide applications in biomedical researches. Purpose: The aim is to study the Fe3O4 nanoparticle-protein interactions and their bioeffects. Methods: Transmission electron microscope (TEM)

light microscopy

SDS-PAGE (Sodium Dodecyl Sulfonate-Polyacrylamide Gelelectrophoresis)

Bradford and MTT (3-(4

5-dimethyl-2-thiazolyl)-2

5-diphenyl-2-H-tetrazolium bromide) methods were used to investigate the Fe3O4 nanoparticle-protein interactions and their bioeffects. Results: The adsorption capacities of Fe3O4 nanoparticle for different proteins were different

and the order was fibrinogen>immunoglobulin>albumin. The adsorption of proteins on the Fe3O4 surface resulted in much reduced cytotoxicity for these protein-coated Fe3O4 nanoparticles. Conclusion: These findings suggest that we should take the Fe3O4 nanoparticle-protein interactions into consideration when designing safe Fe3O4 nanoparticles for biomedical applications. Abstract

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