Radio-synthesis and application research advance of amino acid molecular tracers labeling with 18F and 11C for tumor PET imaging

HE Shanzhen; WANG Shuxia; WANG Peng; LI Shilei; TANG Ganghua

doi:10.11889/j.0253-3219.2014.hjs.37.080302

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Radio-synthesis and application research advance of amino acid molecular tracers labeling with 18F and 11C for tumor PET imaging

更新时间：2021-03-03

- Radio-synthesis and application research advance of amino acid molecular tracers labeling with 18F and 11C for tumor PET imaging
- NUCLEAR TECHNIQUES Vol. 37, Issue 8, Article number: 080302(2014)
- 作者机构：
  
  1. 广东省人民医院广东省医学科学院
  2. ,广州,510080
- 作者简介：
- 基金信息：
- DOI：10.11889/j.0253-3219.2014.hjs.37.080302
  CLC：
- Published：22 July 2014
- 稿件说明：
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HE Shanzhen, WANG Shuxia, WANG Peng, et al. Radio-synthesis and application research advance of amino acid molecular tracers labeling with 18F and 11C for tumor PET imaging[J]. Nuclear techniques, 2014, 37(8): 080302
DOI：

HE Shanzhen, WANG Shuxia, WANG Peng, et al. Radio-synthesis and application research advance of amino acid molecular tracers labeling with 18F and 11C for tumor PET imaging[J]. Nuclear techniques, 2014, 37(8): 080302 DOI： 10.11889/j.0253-3219.2014.hjs.37.080302.

摘要

PET/CT显像作为一种诊断肿瘤、评价疗效和预后的有力工具得到了快速的发展。氨基酸类正电子药物被临床证明是可以弥补当前18F-FDG PET/CT不足的重要药物，不像18F-FDG，氨基酸类分子探针在正常脑组织中的摄取很低，在良性的病变如炎症、水肿、坏死和纤维化的组织几乎不摄取，可以提高PET/CT显像的特异性，其合成标记的研发日益得到重视。本文重点介绍了当前利用短半衰期正电子核素18F和11C标记合成正电子类氨基酸的方法学和初步应用研究的最新进展。

Abstract

Background: Positron emission tomography (PET) is in rapidly developing as a powerful imaging technique for diagnosis

efficacy evaluation and prognosis of tumor. In contrast to 18F-FDG

the amino acid tracers were helpful additional tools for differentiating tumor tissue and inflammation

edematous

necrotic and fibrotic tissue because of their low uptake in those tissues

so that amino acid tracers appear to be more specific than the widely used 18F-FDG. As a result

a number of attempts have been undertaken for radio-synthesis of amino acid with short half-life nuclide 18F and 11C. Purpose: The aim is to review and discuss the present knowledge on synthesis methods and preliminary clinic application of labeling amino acid. Methods: The advances on the synthesis methods and preliminary clinic application of labeling amino acid in recent years were introduced and discussed. Results: In recent years

many new 18F or 11C-labeled amino acids have been developed and their preliminary clinic applications were studied. Conclusion: The review provides an overview of this class of radiolabeled amino acids and highlights the current synthesis status and the key preliminary clinic applications. Abstract

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