Background: The rapid development of nuclear technique makes the actinides uranium be used more and more widely

which increases the chances of nuclear accident. Accident caused by radiation not only displays direct illumination to body surface

but more serious the internal. Purpose: The aim is to investigate whether fullerenes derivatives have protective effect on acute liver injury. Methods: In this work

we modified fullerenes based on their strong radical scavenging function and investigated whether fullerene derivative has a protective effect against liver mitochondria damage in mice. Results: Experimental results show that the radiation can generate strong free radical and damage on mitochondria. Damages are as follows: mitochondria swelling

lipid peroxidation producing and malondialdehyde (MDA) generating. Conclusion: Chelating agent can significantly reduce the swelling of mitochondria and the formation of MDA

so as to maintain the integrity structure and function of mitochondria. Abstract