HOU Xiaoxiao, TANG Xiaobin, GENG Changran, et al. Feasibility and improvement of biological imaging technique based on Cerenkov effect[J]. Nuclear techniques, 2014, 37(7): 070202
DOI:
HOU Xiaoxiao, TANG Xiaobin, GENG Changran, et al. Feasibility and improvement of biological imaging technique based on Cerenkov effect[J]. Nuclear techniques, 2014, 37(7): 070202 DOI: 10.11889/j.0253-3219.2014.hjs.37.070202.
Feasibility and improvement of biological imaging technique based on Cerenkov effect
Background: There are several defects in traditional optical imaging such as background interference
toxic fluorescence stain
low stability etc. Similar problems can be avoided by use of Cerenkov light for optical imaging. Purpose: This work is to confirm the feasibility of Cerenkov light imaging in theory
find the shortage of Cerenkov light imaging
seek the feasible solution. Methods: Using the Monte Carlo method
(1) Simulate the condition that decay particles from three kinds of radioactive source (18F
131I
32P) produce Cerenkov light
analyze the relationship between thickness of the muscle and the number of Cerenkov photons; (2) Exchange the radioactive source to light source
analyze the penetration of photon in different wavelengths within Cerenkov light wavelength range. Results: The feasibility of Cerenkov light imaging is verified by using Monte Carlo method
penetrability of single Cerenkov light is poor
however
penetrability appears better of Cerenkov light in long wavelength. Conclusion: Cerenkov light imaging can be used as a novel imaging method
it has promising application. The problem of poor penetrability can be solved by giving a way to make the wavelength of Cerenkov light "red-shift". Abstract