Strategy for securing the national supply of radioisotopes

WANG Yongxian

doi:10.11889/j.0253-3219.2013.hjs.36.030301

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Strategy for securing the national supply of radioisotopes

更新时间：2021-06-03

- Strategy for securing the national supply of radioisotopes
- NUCLEAR TECHNIQUES Vol. 36, Issue 3, Article number: 030301(2013)
- 作者机构：
  
  中国科学院上海应用物理研究所
- 作者简介：
- 基金信息：
- DOI：10.11889/j.0253-3219.2013.hjs.36.030301
  CLC： O562.6
- Published：2013
- 稿件说明：
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[1]汪勇先.关于保障我国同位素供应安全的考虑[J].核技术,2013,36(03):44-47.

WANG Yongxian. Strategy for securing the national supply of radioisotopes[J]. Nuclear techniques, 2013, 36(3): 030301
[1]汪勇先.关于保障我国同位素供应安全的考虑[J].核技术,2013,36(03):44-47. DOI： 10.11889/j.0253-3219.2013.hjs.36.030301.

WANG Yongxian. Strategy for securing the national supply of radioisotopes[J]. Nuclear techniques, 2013, 36(3): 030301 DOI： 10.11889/j.0253-3219.2013.hjs.36.030301.

摘要

全球的放射性同位素生产反应堆严重老化

导致故障频发

造成全球同位素供应短缺

已严重影响临床诊断和治疗以及核分子影像技术的发展。发展新的替代技术解决同位素的供应短缺已是刻不容缓。基于加速器的99mTc生产技术已日趋成熟

加速器生产的99mTc在核纯度

比活度和非放杂质等方面已达到或超过反应堆生产的裂变钼制备的钼锝发生器生产的99mTc。基于加速器的医用放射性同位素区域性集中供应模式

取代传统的基于反应堆的全球集中供应模式是保证我国医用同位素供应安全的最具可操作性和可持续性的发展途径。

Abstract

Background: The global supply shortage of medical radioisotopes caused by the unscheduled shutdown of the aged reactors which supply over 90% of radioisotopes overall the world

has severely affected the normal healthcare system which depend on the technology of molecular imaging for diagnoses and therapy as well as the development of nuclear molecular imaging technology.Purpose: It is urgently needed to develop new alternative technologies to solve the problem of global radioisotope supply shortage.Methods: The proton cyclotron is a potential alternative technology to produce the99mTc and the most of medical radioisotopes of clinical importance.Results: The quality of 99mTc produced by cyclotron

such as nuclide purity

specific activity and nonradioisotope impurities

has reached and/or exceeded that eluted from99Mo/99mTc generator produced by reactor.Conclusions: It is the most operational and sustainable way to substitute the conventional global centralized supply by reactors with local centralized supply of radioisotopes by proton cyclotrons for securing the national supply of radioisotopes.

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Related Institution

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Department of nuclear science and technology, Nanjing University of Aeronautics and Astronautics

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Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Jiading Campus

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