Synthesis of <sup>3</sup>H-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine hydrochloride

Zhang Hongliang

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Synthesis of ³H-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine hydrochloride

更新时间：2021-04-20

- Synthesis of ³H-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine hydrochloride
- NUCLEAR TECHNIQUES Issue 9, (1991)
- 作者机构：
  
  1. 中国科学院上海药物研究所
  2. 中国科学院上海原子核研究所
  3. 中国科学院上海药物研究所中国科学院上海原子核研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：01 September 1991
- 稿件说明：
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[1]张鸿良,张年宝.~3H-MPTP盐酸盐的合成[J].核技术,1991(09):573-576.

Zhang Hongliang. Synthesis of ³H-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine hydrochloride[J]. Nuclear techniques, 1991, (9): 573-576.
[1]张鸿良,张年宝.~3H-MPTP盐酸盐的合成[J].核技术,1991(09):573-576. DOI：

Zhang Hongliang. Synthesis of ³H-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine hydrochloride[J]. Nuclear techniques, 1991, (9): 573-576. DOI：

摘要

本文报道了神经毒素MPTP盐酸盐的氚标记物——

H-MPTP盐酸盐的合成。首先通过1

4-二溴苯与N-甲基哌啶酮经格氏反应合成了1-甲基-4-（4′-溴代苯）-4-羟基哌啶

然后该前体经卤-氚交换和盐酸脱水反应制得[4′-

H]-1-甲基-4-苯基-1

6-四氢吡啶（

H-MPTP）盐酸盐。其放射性比活度为1.16TBq/mmol

放化纯度

95％。

Abstract

This paper reported the synthesis of [4’-3H]-1-methyl-4-pheny 1-1

6-tetrahydroa pyridine hydrochloride （3H-MPTP.HC1） from l-methyl-4-（4’-bromophenyl）-4-hydroxyl-piperidine through catalytic halogen-tritium replacement. The tritiated product was obtained with a specific radioactivity of 1.16 TBq/mmol and a radiochemical purity over 95%.

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Synthesis of 3H-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine hydrochloride

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摘要

Abstract

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references

Synthesis of ³H-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine hydrochloride