Experimental study on the radioinjury action of （90）<sup>Y</sup> labelled resin

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Experimental study on the radioinjury action of （90）^Y labelled resin

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- Experimental study on the radioinjury action of （90）^Y labelled resin
- NUCLEAR TECHNIQUES Issue 11, (1998)
- 作者机构：
  
  1. 中国医学科学院中国协和医科大学北京协和医院,北京
  2. ,100730
- 作者简介：
- 基金信息：
- DOI：
  CLC： R730.5
- Published：01 November 1998
- 稿件说明：
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[1]杨子义,杨宁,王世真.~(90)Y-树脂用于放射杀伤的实验研究[J].核技术,1998(11):701-704.

Experimental study on the radioinjury action of （90）^Y labelled resin[J]. Nuclear techniques, 1998, (11): 701-704.
[1]杨子义,杨宁,王世真.~(90)Y-树脂用于放射杀伤的实验研究[J].核技术,1998(11):701-704. DOI：

Experimental study on the radioinjury action of （90）^Y labelled resin[J]. Nuclear techniques, 1998, (11): 701-704. DOI：

摘要

用Dowex50树脂吸附90Sr-90Y平衡体制成90Y发生器，用柠檬酸钠缓冲液淋洗得到90Y。在pH≥8．0时，90Y与Bio－Rex70树脂结合4h，结合率达90％以上。90Y标记树脂经动脉导管选择性地注入狗的右下肝叶，给药后4h内血中90Y的总量约为给药总剂量的1％。两周后X－CT成像显示，给药肝叶呈液化性坏死，大体标本观察见给药肝叶萎缩，病理检查见肝细胞成片死亡。结果表明，90Y标记树脂是一种有效、安全的放射杀伤制剂，结合选择性动脉导管给药，可以试用于肿瘤病灶的放射治疗。

Abstract

90Y generator was made by absorption 90Sr-90Y equilibrium system to Dowex 50 resin. 90Y was obtained by elution with sodium citrate buffer solution. The 90Y was mixed with Biou-Rex 70 resin

high binding rate were achieved when the pH value was more than eight and the mixing duration was 4 h.90Y labelled resin was injected through hepatic artery catheter into the right lower lobe of liver in dog. The total blood concentration of 90Y was estimated to be 1% of total dose administered.After 2 weeks

X-CT showed that the administered liver lobe observed liquified necrosis and liver atrophy grossly

also liver cell die away extensive1y in pathological sections.These prelimenary findings suggested that with selective administration of hepatic artery catheterization

radiolabelled resin was an effective and safe radioinjury reagent

and can be used for tumor radiotherapy.

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Experimental study on the radioinjury action of （90）Y labelled resin

DOI：

摘要

Abstract

关键词

Keywords

references

Experimental study on the radioinjury action of （90）^Y labelled resin