To explore the relationship between PRL

GH（RIA）

GH（RRA） serum levels changes and the onset and development of disease in patients with SLE

and to understand the hormonal changes in active and inactive phase of disease

28 cases and 20 controls were studied. The results showed that anti-ds-DNA serum level in active and inactive phases was higher than those in controls （P<0.01）

and also there was significant difference between active and inactive phase （P<0.01）. Morever

there is significant difference in PRL level between the patients in active phase and the controls （P<0.05）

also in GH serum level between the patients and the controls （P1<0.01） and the patients in inactive phase （P2<0.05）. This study indicated that the higher serum level of PRL

GH（RIA）

GH（RRA） is correlated with some autoimmune characteristics of SLE

especially in its active phase. Therefore it gives some help for clinical study of SLE.