The preparation and preliminary animal experiment of （188）<sup>R</sup>e-HEDP

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The preparation and preliminary animal experiment of （188）^Re-HEDP

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- The preparation and preliminary animal experiment of （188）^Re-HEDP
- NUCLEAR TECHNIQUES Issue 11, (1998)
- 作者机构：
  
  1. 解放军总医院,北京
  2. 北京市肿瘤医院,北京
  3. 中国原子能科学研究院同位素研究所,北京
  4. ,102413
- 作者简介：
- 基金信息：
- DOI：
  CLC： R73-36
- Published：01 November 1998
- 稿件说明：
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[1]张锦明,田嘉禾,杨志,尹大一,金小海,白红升.~(188)Re-HEDP的制备和初步动物实验[J].核技术,1998(11):697-700.

The preparation and preliminary animal experiment of （188）^Re-HEDP[J]. Nuclear techniques, 1998, (11): 697-700.
[1]张锦明,田嘉禾,杨志,尹大一,金小海,白红升.~(188)Re-HEDP的制备和初步动物实验[J].核技术,1998(11):697-700. DOI：

The preparation and preliminary animal experiment of （188）^Re-HEDP[J]. Nuclear techniques, 1998, (11): 697-700. DOI：

摘要

用188W／188Re发生器淋洗液制备了骨肿瘤治疗剂188Re－HEDP。188Re－HEDP的最佳标记条件为：5mgHEDP，2.0mgSnCl2和1mgVc。在pH2．0的条件下，标记率大于95％，其体外12h内稳定性良好。在制备188Re－HEDP时加入辅剂，注射后4h，小鼠股骨摄取为（7.86±1．62）％ID／g；而对照组仅有（1．92±0.61）％ID／g（P＜0.01）。兔全身显像清晰，说明188Re－HEDP是一个很有前途的骨肿瘤治疗剂。

Abstract

188Re-HEDP have been prepared with 188Re eluted from a 188W/188Re generator.The best labelling condition is 5 mg HEDP

2.0mg SnCl2

and 1 mg Vitamin C

PH2.0.Labelling yield is greater than 95%. The in vitro stability of 188Re-HEDP is good in 12 hours. By adding some adjunct reagent in preparation

femur uptake raised to 7.86 ±1.62%/g after 4 hours. As compared with control uptake 1.92±0.61%/g in mice （P<0.01）. Clear whole body images of rabbit has been obtained. Thereby 188Re-HEDP is a good potential candidate for the treatment of bone tumor.

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The preparation and preliminary animal experiment of （188）Re-HEDP

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摘要

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The preparation and preliminary animal experiment of （188）^Re-HEDP