The distribution and excretion of nerve growth factor in mice

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The distribution and excretion of nerve growth factor in mice

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- The distribution and excretion of nerve growth factor in mice
- NUCLEAR TECHNIQUES Issue 11, (1998)
- 作者机构：
  
  1. 中国医学科学院中国协和医科大学北京协和医院,北京
  2. ,100730
  3. 中国医学科学院中国协和医科大学基础医学研究所,北京
  4. 中国医学科学院中国协和医科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R96
- Published：01 November 1998
- 稿件说明：
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[1]姜国辉,唐刚华,陈力真,张云,王世真,王树惠.神经生长因子在小鼠体内的分布与排泄实验研究[J].核技术,1998(11):649-652.

The distribution and excretion of nerve growth factor in mice[J]. Nuclear techniques, 1998, (11): 649-652.
[1]姜国辉,唐刚华,陈力真,张云,王世真,王树惠.神经生长因子在小鼠体内的分布与排泄实验研究[J].核技术,1998(11):649-652. DOI：

The distribution and excretion of nerve growth factor in mice[J]. Nuclear techniques, 1998, (11): 649-652. DOI：

摘要

采用氯胺-T法对神经生长因子（Nervegrowthfactor，NGF）进行碘标记，研究了NGF在小鼠体内的分布与排泄规律。结果表明：NGF在小鼠体内组织器官的分布速率以颈上神经节、甲状腺、胆囊、肾脏、肾上腺等组织较快，各器官的达峰时间为20—30min；肌注125I－NGF72h内，小鼠粪尿中放射性排泄总量达72．55％，其中尿内累积量约占排泄总量的65.64％，而粪便中只占不足7％。

Abstract

Nerve growth factor（NGF） was iodolabelled with chloramine-T method and its distribution and excretion in mice were investigated. The results showed that the highest levels were found in superior cervical ganglia

thyroid

bile

kidneys and adrenals between 20-30 min after injection

and the peak time in most tissues was also found at 20-30 min. About 72.55% of the injected dose was excreted in stool and urine

among them 65.6% was excreted in urine and only 7.0% in stool within 72h after intramuscular injection.

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