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1. 江苏省原子医学研究所核医学国家重点实验室,无锡
2. ,214063
Published:01 November 1998
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[1]周翔,方平,吴春英,陈正平.[~(99m)TC≡N]标记中间体的制备及特性[J].核技术,1998(11):656-658.
Synthesis and characteristics of the [(99m)Tc≡N] intermediate[J]. Nuclear techniques, 1998, (11): 656-658.
报道了两种制备[99mTc≡N]中间体的方法。在N的供体及还原剂(TPPS,SnCl2)存在的条件下制备[99mTc≡N]中间体,两种方法制得的中间体的组成不同,但均为混合物,而且与配体反应,都可以制得以[99mTc≡N]2+为中心核的配合物。用HPLC检测标记中间体在不同pH时的组成变化及稳定性情况。
Two methods for the synthesis of the [99mTc≡N] intermediates were reported. In the presence of reducer (TPPS or SnCl2) and the donor of N
the mixture of [99mTc≡N] intermediate could be conveniently synthesized but with different composition. On reaction with ligands complexes containing [99mTc≡N]2+ core can be obtained. The change of composition of Intermediates was detected by HPLC at different PH values
and the stability was also evaluated.
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