A study on the metabolism of Cr（Ⅲ） in rats by radioactive tracer technique

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A study on the metabolism of Cr（Ⅲ） in rats by radioactive tracer technique

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- A study on the metabolism of Cr（Ⅲ） in rats by radioactive tracer technique
- NUCLEAR TECHNIQUES Issue 12, (1998)
- 作者机构：
  
  1. 中国科学院高能物理研究所!中国科学院核分析技术开放实验室北京
  2. ,100080
- 作者简介：
- 基金信息：
- DOI：
  CLC： +
- Published：01 December 1998
- 稿件说明：
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[1]丰伟悦,丁文军,钱琴芳,柴之劳.用放射性示踪技术研究Cr(Ⅲ)在大鼠体内的代谢规律[J].核技术,1998(12):731-736.

A study on the metabolism of Cr（Ⅲ） in rats by radioactive tracer technique[J]. Nuclear techniques, 1998, (12): 731-736.
[1]丰伟悦,丁文军,钱琴芳,柴之劳.用放射性示踪技术研究Cr(Ⅲ)在大鼠体内的代谢规律[J].核技术,1998(12):731-736. DOI：

A study on the metabolism of Cr（Ⅲ） in rats by radioactive tracer technique[J]. Nuclear techniques, 1998, (12): 731-736. DOI：

摘要

用放射性示踪技术，通过灌胃方式研究了51Cr3+在雄性Wistar大鼠体内的代谢行为。发现占灌胃量99．6％的51Cr从粪便排出，吸收率＜1％。进入体内的51Cr的蓄积量是肝＞肌肉＞胰＞骨骼＞肾。单位重量胰脏中51Cr的蓄积量最高，这表明胰脏可能是体内铬的敏感器官。用房室模型描述51Cr在大鼠体内的代谢行为；可以归结为三室模型，说明Cr（Ⅲ）在大鼠体内的吸收及在组织脏器中的分布速率很快，在某些脏器及组织中的蓄积稳定，清除缓慢。

Abstract

The 51Cr3+ was intragastrically administered into rats and its absorption

distribution and excretion in various organs were studied at time intervals of 1

48 and 72 hours by the radioactive tracer technique. About 99.6% of the administered chromium was excreted in feces showing that the absorption of 51Cr was less than 1%. The absorbed chromium was accumulated in many organs

in an order of liver>muscle>pancreas>bone>kidney. The fact that the specific activity in pancreas was the highest of all the studied organs indicated that pancreas might be a sensitive organ to 51Cr3+ in the body. The data of 51Cr3+ in blood was proved to fit the three compartments model

suggesting that there were two chromium clearance models in the body-one was quick and the other was slow or stable.

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