Synthesis of [2-<sup>15</sup>N] -perlolyrine

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Synthesis of [2-¹⁵N] -perlolyrine

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- Synthesis of [2-¹⁵N] -perlolyrine
- NUCLEAR TECHNIQUES Issue 12, (1998)
- 作者机构：
  
  1. 中国医学科学院中国协和医科大学北京协和医院,北京
  2. ,100730
- 作者简介：
- 基金信息：
- DOI：
  CLC： O629
- Published：01 December 1998
- 稿件说明：
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[1]唐刚华,王世真,吴淑琴,姜国辉.[2-~(15)N]-川芎哚的合成研究[J].核技术,1998(12):737-739.

Synthesis of [2-¹⁵N] -perlolyrine[J]. Nuclear techniques, 1998, (12): 737-739.
[1]唐刚华,王世真,吴淑琴,姜国辉.[2-~(15)N]-川芎哚的合成研究[J].核技术,1998(12):737-739. DOI：

Synthesis of [2-¹⁵N] -perlolyrine[J]. Nuclear techniques, 1998, (12): 737-739. DOI：

摘要

以糠醛为起始原料，经乙酰化、甲酰化后，与中间原料[α－15N]－dl－色氨酸发生氧化（芳香化）、脱羧、水解等反应生成[2－15N]－川芎哚。终产物经MS、UV、TLC等证实。产率为15．5％，15N的丰度为92％。结果表明，合成的[2－15N]－川芎哚符合药理实验要求。

Abstract

The synthesis of [2-15N]-perlolyrine is described. Furfuryl alcohol was first acetylated and formacylated

and then reacted with [α -15N]-dl-tryptophan to form the ring-closed product

which was oxidated and hydrolyzed to give the final product. The product was confirmed by MS

UV and TLC. Its yield from [α -15N]-dl-tryptophan was 15.5%

and the abundance of 15N was 92%. The synthetic [2- 15N]-perlolyrine is therefore suitable for pharmacologic experiments.

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Synthesis of [2-15N] -perlolyrine

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摘要

Abstract

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Synthesis of [2-¹⁵N] -perlolyrine