Micronucleus formation and its sustained action in bone marrow  cells induced by absorption dose of         134  Cs in skeleton

Zhu Shoupeng   Xia Fen   Yang Weidong

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Micronucleus formation and its sustained action in bone marrow cells induced by absorption dose of 134 Cs in skeleton

更新时间：2021-04-09

- Micronucleus formation and its sustained action in bone marrow cells induced by absorption dose of 134 Cs in skeleton
- NUCLEAR TECHNIQUES Issue 5, (1997)
- 作者机构：
  
  苏州医学院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R681
- Published：01 May 1997
- 稿件说明：
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[1]朱寿彭,夏芬,杨卫东.~(134)Cs 的骨吸收剂量诱发骨髓 PCE 微核率及其持续作用[J].核技术,1997(05):33-36.

Zhu Shoupeng Xia Fen Yang Weidong. Micronucleus formation and its sustained action in bone marrow cells induced by absorption dose of 134 Cs in skeleton[J]. Nuclear techniques, 1997, (5).
[1]朱寿彭,夏芬,杨卫东.~(134)Cs 的骨吸收剂量诱发骨髓 PCE 微核率及其持续作用[J].核技术,1997(05):33-36. DOI：

Zhu Shoupeng Xia Fen Yang Weidong. Micronucleus formation and its sustained action in bone marrow cells induced by absorption dose of 134 Cs in skeleton[J]. Nuclear techniques, 1997, (5). DOI：

摘要

研究了机体内污染１３４Ｃｓ在小鼠骨骼中的滞留过程和吸收剂量诱发骨髓嗜多染红细胞（ＰＣＥ）微核率的量效关系及其持续作用特性。由１３４Ｃｓ在骨骼中滞留动态拟合方程导出其半滞留期为５．７３天；１３４Ｃｓ诱发骨髓ＰＣＥ的微核形成率随机体摄入１３４Ｃｓ放射性活度的增加而升高，且在骨髓ＰＣＥ微核形成率（Ｙ，％）与摄入１３４Ｃｓ放射性活度（Ｘ，ｋＢｑ／ｇ）之间呈现幂函数关系（Ｙ＝０．２４６Ｘ０．３０７）；由于１３４Ｃｓ内照射的作用持续性，其诱发的骨髓ＰＣＥ微核率在连续４７天的观察中仍持续增升。

Abstract

In this paper sustained effect of micronucleus formation in bone marrow cells induced by absorption dose of 134 Cs in skeleton was studied. The results indicated that a fitted equation to describe the retention of 134 Cs in bone marrow cells is obtained as follows: R（t）=0.0029e -0.121t . Where the T 1/2 in skeleton is 5.73d. Experimental results showed that obvious increase of micronucleus formation could be induced by 134 Cs with a threshold dose as 0.93kBq/g. The relations between injected dose（X

kBq/g） and micronucleus formation rates（Y

%） can be expressed by an power function Y=0.246X 0.307 . In accordance with the peculiarity of internal exposure with 134 Cs

sustained effect of micronucleus formation in bone marrow cells may continued to 47 days.

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