The synthesis of[1 14 C]palmitic acid via Grignard Reaction is reported The carbon C 14 dioxide was liberated by dropping sulfuric acid onto barium carbonate C 14 The yield of [1 14 C] palmitic acid was 44 8% A radiochemical purity of more than 99 5% was determined by HPLC and the product was proved to be free of impurity by TLC