A study of ￣（99m）Tc- EC in mice and its preliminary clinical application

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A study of ￣（99m）Tc- EC in mice and its preliminary clinical application

更新时间：2021-04-09

- A study of ￣（99m）Tc- EC in mice and its preliminary clinical application
- NUCLEAR TECHNIQUES Issue 5, (1994)
- 作者机构：
  
  江苏省原子医学研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC： Q95-3
- Published：01 May 1994
- 稿件说明：
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[1]匡琴芳,吴春英,吴鹏西,方平,冯瑛瑛.~（99m）Tc－EC的动物研究及初步临床评价[J].核技术,1994(05):289-292.

A study of ￣（99m）Tc- EC in mice and its preliminary clinical application[J]. Nuclear techniques, 1994, (5).
[1]匡琴芳,吴春英,吴鹏西,方平,冯瑛瑛.~（99m）Tc－EC的动物研究及初步临床评价[J].核技术,1994(05):289-292. DOI：

A study of ￣（99m）Tc- EC in mice and its preliminary clinical application[J]. Nuclear techniques, 1994, (5). DOI：

摘要

研究显示了９９ｍＴｃ－ＥＣ的化学量对小鼠肾放射量浓聚有很大的影响，只有当鼠接受１．２５ｍｇ／ｋｇ剂量时肾的放射量最高．肾／肝达３．２。它的小鼠毒性和与血浆蛋白的结合率均低．１４例健康志愿者肾显像表明９９ｍＴｃ－ＥＣ是一种有用的锝标记肾功能显像剂．

Abstract

Mouse experiment revealed that the concentration of 99mTc-EC in kidney was highly dependent on the chemical amount of the injected tracer.A highest concentration in kideney was found at a dose of 1.25 mg per kg of body weight

with a kidney/liver ration as high as 3.2.Its toxicity was low and only a small percentage was bound to plasma protein. Preliminary study on 14 healthy volunteers suggests that 99mTc- EC is a hopeful functional imaging agent for kidney.

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