Pharmacokinetics of recombinant human erythropoietin in rats and human

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Pharmacokinetics of recombinant human erythropoietin in rats and human

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- Pharmacokinetics of recombinant human erythropoietin in rats and human
- NUCLEAR TECHNIQUES Issue 11, (1994)
- 作者机构：
  
  上海医科大学附属中山医院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R983
- Published：01 November 1994
- 稿件说明：
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[1]丁小强,陈可靖,陈秋潮,吴兆龙,廖履坦.人基因重组红细胞生成素在大鼠和人体的药物动力学研究[J].核技术,1994(11):680-683.

Pharmacokinetics of recombinant human erythropoietin in rats and human[J]. Nuclear techniques, 1994, (11).
[1]丁小强,陈可靖,陈秋潮,吴兆龙,廖履坦.人基因重组红细胞生成素在大鼠和人体的药物动力学研究[J].核技术,1994(11):680-683. DOI：

Pharmacokinetics of recombinant human erythropoietin in rats and human[J]. Nuclear techniques, 1994, (11). DOI：

摘要

正常ＳＤ大鼠皮下注射ｒＨｕＥＰＯ（人基因重组红细胞生成素）的Ｆ参数（相对生物利用度）显著高于腹腔注射．单次皮下注射１００Ｕ／ｋｇ时，正常人、尿毒症未透析和腹透组ｔ１／２β（消除相半衰期）分别为１５．４±０．９、１６．６±６．９和９．２±２．７ｈ．在尿毒症未透析组，皮下注射后血药浓度下降缓慢，Ｆ为（４１±１７）％，用药４８ｈ后仍为基础浓度的３倍左右。表明ｒＨｕＦＰＯ以皮下用药更为合适。

Abstract

The mean biovailability（F） after s.c. injection of rHuEPO was signincantly higher than that after i.p. injection in healthy SD rats. The mean t1/2β after a s.c.dose of 100U/kg in normal human volunteers

pre-dialysis and peritoneal dialysis uremic patients were 15.4 ± 0.9

16.6 ± 6.9 and 9.2 ± 2.7 h respectively. In pre-dialysis patients

the mean F after a s.c. dose was 41 ± 17%. Serum rHuEPO concentrations after a s.c. dose decreased slowly and were over three times of baseline 48 hours later. It is concluded that s.c. administration is the optical route for rHuEPO.

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