Preliminary observation of￣（131）I-lipiodol internal radiation therapy for liver cancer

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Preliminary observation of￣（131）I-lipiodol internal radiation therapy for liver cancer

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- Preliminary observation of￣（131）I-lipiodol internal radiation therapy for liver cancer
- NUCLEAR TECHNIQUES Issue 11, (1994)
- 作者机构：
  
  西安医科大学第一临床医学院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R454.2
- Published：01 November 1994
- 稿件说明：
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[1]胡国瑛,王居邠,潘承恩,喻铭启.~（131）Ⅰ－碘化油内照射治疗肝癌的初步观察[J].核技术,1994(11):693-696.

Preliminary observation of￣（131）I-lipiodol internal radiation therapy for liver cancer[J]. Nuclear techniques, 1994, (11).
[1]胡国瑛,王居邠,潘承恩,喻铭启.~（131）Ⅰ－碘化油内照射治疗肝癌的初步观察[J].核技术,1994(11):693-696. DOI：

Preliminary observation of￣（131）I-lipiodol internal radiation therapy for liver cancer[J]. Nuclear techniques, 1994, (11). DOI：

摘要

报道了１３１Ⅰ－碘化油经肝动脉注射（Ａ法）或Ｂ超导向经皮穿刺注射（Ｂ法）治疗２０例肝癌的初步观察．放射性核素显像证实１３１Ⅰ－碘化油主要浓集于肿瘤内。Ａ法及Ｂ法的癌肝比值分别为３．８７±２．７７及９．１５±３．４１；１３１Ⅰ－碘化油在癌内的有效半减期分别为４．７±１．９２ｄ及６．２２±０．６１ｄ，肺内放射性（肺／肺＋肝）为１３．１９±３．０１％及５．１９±２．２８％，说明Ｂ法的生物学分布优于Ａ法。临床结果ＡＦＰ下降占６４．３％，肿瘤缩小占６６．７％，除有短暂发热及胆红质、ＳＧＰＴ增高外，未见其它毒副反应．

Abstract

Internal radiation therapy of 131 I- lipiodol with hepatic artery injection（Method A） and B-ultrasound guided percutaneous puncture（Method B） was observed in twenty patients with liver cancer. The radionuclide images showed that the 131I-lipiodol acumulated in tumor mainly. The radioactivity of tumor/liver （T/L）ratio in method A and method B was 3.87 ± 2.77 and 9.15 ± 3.41

the effective half-life of 131I- lipiodol in tumor was 4.7 ± 1.92 days and 6.22 ± 0.61 days

and the radioactivity of lung was 13.19 ± 3.01% and 5.19 ± 2.28% respectively. These results suggested that the 131 I- lipiodol biodistribution in method B is better than method A. Clinical results showed that AFP levels dropped rapidly in 64.3% of the patients with positive AFP.A shrinkage in tumor size was observed in 66.7% of patients. With the transient fever

elevated bilirubin and SGPT in some patients

no other toxicity and adverse reactions were observed.

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