The direct labelling of IgG with￣（99m）Tc and its stability studies

您当前的位置：

首页 >

文章列表页 >

The direct labelling of IgG with￣（99m）Tc and its stability studies

更新时间：2021-04-09

- The direct labelling of IgG with￣（99m）Tc and its stability studies
- NUCLEAR TECHNIQUES Issue 11, (1994)
- 作者机构：
  
  上海医科大学附属华山医院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R446.42
- Published：01 November 1994
- 稿件说明：
移动端阅览
[1]顾兆祥,薛方平,林祥通.~（99m）Tc直接标记IgG及其稳定性研究[J].核技术,1994(11):642-645.

The direct labelling of IgG with￣（99m）Tc and its stability studies[J]. Nuclear techniques, 1994, (11).
[1]顾兆祥,薛方平,林祥通.~（99m）Tc直接标记IgG及其稳定性研究[J].核技术,1994(11):642-645. DOI：

The direct labelling of IgG with￣（99m）Tc and its stability studies[J]. Nuclear techniques, 1994, (11). DOI：

摘要

采用二硫苏糖醇还原ＩｇＧ和合亚锡的药盒还原高锝酸盐法将９９ｍＴｃ直接标记ＩｇＧ。其标记率＞９５％，标记后无需纯化。使用多种弱交换配体（亚锡ＰＹＰ、ＭＤＰ、ＧＨ、Ｐｈｙｔａｔｅ和ＥＨＩＤＡ药盒）获得了高的标记率，但此法不宜用ＤＴＰＡ药盒．体外研究和显像表明９９ｍＴｃ－ＩｇＧ的稳定性良好，可用于局部实验性脓肿的诊断。

Abstract

he immunoglobulin G（IgG） was directly labelled with 99mTc by prereduction of IgG with dithiothreitol and redution of pertechnetate wiht a stannous kit. The radiochemical purity was over 95% .Hence no purification was needed

High labelling dfficiency could be obtained with a variety of weak exchange ligands

such as PYP

MDP

Phytate and EHIDA kits

But DTPA was not effective substance for this procedure. iN vitro studies and the animal imaging showed that 99mTc -IgG was stable useful in diagnosis of focal experimental abscess.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

No data

Related Author

No data

Related Institution

No data

AI问答

Address：2019 Jialuo Road, Jiading, Shanghai, China Postal code：201800
Tel：021-39194977 Email：LHB@sinap.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 沪ICP备05005479号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
Total Visits：880771 Visits Today：298

⁰