Immunoreactivity of <sup>125</sup>I-anti-Tg-McAb to thyroid carcinoma cell in vitro

Ma Qingjie Zhao Jie Xiao Yanling

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Immunoreactivity of ¹²⁵I-anti-Tg-McAb to thyroid carcinoma cell in vitro

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- Immunoreactivity of ¹²⁵I-anti-Tg-McAb to thyroid carcinoma cell in vitro
- NUCLEAR TECHNIQUES Issue 11, (1993)
- 作者机构：
  
  1. 白求恩医科大学三院
  2. 白求恩医科大学三院,长春,130021
- 作者简介：
- 基金信息：
- DOI：
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- Published：01 November 1993
- 稿件说明：
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[1]马庆杰,赵杰,孝延龄.~(125)I—抗Tg—McAb与甲状腺癌细胞结合的体外实验研究[J].核技术,1993(11):683-686.

Ma Qingjie Zhao Jie Xiao Yanling. Immunoreactivity of ¹²⁵I-anti-Tg-McAb to thyroid carcinoma cell in vitro[J]. Nuclear techniques, 1993, (11): 683-686.
[1]马庆杰,赵杰,孝延龄.~(125)I—抗Tg—McAb与甲状腺癌细胞结合的体外实验研究[J].核技术,1993(11):683-686. DOI：

Ma Qingjie Zhao Jie Xiao Yanling. Immunoreactivity of ¹²⁵I-anti-Tg-McAb to thyroid carcinoma cell in vitro[J]. Nuclear techniques, 1993, (11): 683-686. DOI：

摘要

选用自制的18A

和18A

两株McAb进行体外活细胞结合实验

定量观察

125

I标记的18A

和18A

与正常甲状腺组织细胞及某些肿瘤细胞膜结合的反应性。实验结果显示

125

I-抗Tg-McAb与高分化甲癌细胞的结合率均

30％;与髓样癌结合率为8％-12％;与正常甲状腺和甲状腺良性瘤细胞结合率

10％;其他细胞均

4％。碘标记McAb与正常甲状腺和甲状腺良性瘤细胞的结合率显著低于高分化甲癌（p

0.01）;与非甲状腺源性恶性肿瘤细胞基本上不结合。高分化甲癌细胞与正常甲状腺细胞的结合率比值

单株为3.4—4.3

McAb合剂可达5.0。Ch-T法标记抗Tg-McAb时免疫活性有部分损伤。

Abstract

Immunoreactivity of 125I- anti-Tg- McAb（18A1 and 18A11） with cells of normal thyroid and tumor was determined by cell binding assay. Results showed that the binding percentage found in differentiated throid carcinoma medullary thyroid carcimena

benign thyroid tumor

and other cells was >30%

8%-12%

<10% and <4% respectively. Binding percentage of 125I-McAb with differentiated thyroid carcinoma cells was significantly higher than that of normal thyroid and benign thyroid tumor. No binding with cells of malignant tumor coming from the other tissue was confirmed. Ratio of binding percentage on differentiated thyroid carcinoma with normal thyroid cells was also determined as 3.4-4.3（simple McAb）

and 5.0（"cocktail" McAb）. Therefore both 18A1 and 18A11 can be successfully used for radioimmu-noimaging of differentiated thyroid carcinoma and its metastatic sites.

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Related Institution

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Immunoreactivity of 125I-anti-Tg-McAb to thyroid carcinoma cell in vitro

DOI：

摘要

Abstract

关键词

Keywords

references

Immunoreactivity of ¹²⁵I-anti-Tg-McAb to thyroid carcinoma cell in vitro