Preparation of deuterium and tritium labelled ST-1435

Zhang Nianbao Peng Qingyi Zhong Desong

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Preparation of deuterium and tritium labelled ST-1435

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- Preparation of deuterium and tritium labelled ST-1435
- NUCLEAR TECHNIQUES Issue 9, (1993)
- 作者机构：
  
  1. 中国科学院上海原子核研究所
  2. 中国科学院上海药物研究所,上海,201800
  3. ,上海,200031
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：01 September 1993
- 稿件说明：
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[1]张年宝,彭庆义,钟德松,章辛,徐平.氘和氚标记ST—1435的制备[J].核技术,1993(09):537-539.

Zhang Nianbao Peng Qingyi Zhong Desong. Preparation of deuterium and tritium labelled ST-1435[J]. Nuclear techniques, 1993, (9): 537-539.
[1]张年宝,彭庆义,钟德松,章辛,徐平.氘和氚标记ST—1435的制备[J].核技术,1993(09):537-539. DOI：

Zhang Nianbao Peng Qingyi Zhong Desong. Preparation of deuterium and tritium labelled ST-1435[J]. Nuclear techniques, 1993, (9): 537-539. DOI：

摘要

在氘或氚化溶剂中

16-次甲基-17α-乙酰氧基-19-羧基-孕甾-4-烯-3、20-二酮（Ⅰ）通过脱羧反应制得[10-

H]ST-1435或[10-

H]ST-1435（Ⅱ）。氘标记ST-1435经质谱分析表明有1—3个氘原子掺入到ST-1435分子中去

其中m/e 371（M

）的氘掺入率为22.6％。氚标记ST-1435的比活度为52.5TBq/mol

放化纯度

95％。

Abstract

This paper reports the preparation of deuterium and tritium labelled ST-1435 （19-Nor-16-methylene-17 α-acetoxy-progesterone （Ⅱ）） by decarboxylation of 16-methylene-17α-acetoxy-19-oci acid-pregnen- 4-ene-3

20-dione （Ⅰ） in deuterated or tritiated solvents. Deuterium incorportion rate for m/e 371（M+） was 22.6% as determined by mass spectrometer. The tritiated ST-1435 was obtained with a specific radioactivity of 52.5 TBq/mol and a radiochemical purity of over 95%.

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