Synthesis antl labelling of a new brain perfusion imaging agent <sup>99m</sup>Tc-MRP20

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Synthesis antl labelling of a new brain perfusion imaging agent ^99mTc-MRP20

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- Synthesis antl labelling of a new brain perfusion imaging agent ^99mTc-MRP20
- NUCLEAR TECHNIQUES Issue 11, (1993)
- 作者机构：
  
  1. 江苏省原子医学研究所
  2. 无锡轻工业学院
  3. 无锡轻工业学院卫生部核医学实验室
  4. ,214036
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：01 November 1993
- 稿件说明：
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[1]方平,吴春英,罗世能,冯瑛瑛,谢敏浩,匡琴芳,陶冠军,祝耀初,丁绍东.新的脑灌注显像剂~(99m)Tc—MRP20配体的合成与标记[J].核技术,1993(11):690-694.

Fang Ping Wu Chunying Luo Shineng Feng Yingying Xie MinhaoKuang Qinfang. Synthesis antl labelling of a new brain perfusion imaging agent ^99mTc-MRP20[J]. Nuclear techniques, 1993, (11): 690-694.
[1]方平,吴春英,罗世能,冯瑛瑛,谢敏浩,匡琴芳,陶冠军,祝耀初,丁绍东.新的脑灌注显像剂~(99m)Tc—MRP20配体的合成与标记[J].核技术,1993(11):690-694. DOI：

Fang Ping Wu Chunying Luo Shineng Feng Yingying Xie MinhaoKuang Qinfang. Synthesis antl labelling of a new brain perfusion imaging agent ^99mTc-MRP20[J]. Nuclear techniques, 1993, (11): 690-694. DOI：

报道了N-{2（1H吡咯基甲基）}N’-（4-戊烯-3-酮-2）-1

2-乙二胺（MRP20）的光谱数据与结构相符;元素分析结果与理论值一致;MRP20在室温下用亚锡还原可与

99m

TcO（Ⅲ）生成配合物

标记率和放化纯大于90％。

99mTc- MRP20[N- （2（1H- pyrrolylmethyl））N’-（4- pentene- 3- one- 2）ethane-1

2-diamine]

a new brain perfusion imaging agent is reported in this paper. MRP20 was synthesized and characterized. Its chemical structure was confirmed by IR

NMR

MS and element analysis. Using SnCl2 as reducing agent

MRP20 forms a stable complex with 99mTcO（Ⅲ）. The labelling yield and rediochemical purity were both higher than 90%.

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Jiangsu Institute of Nuclear Medicine

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Synthesis antl labelling of a new brain perfusion imaging agent 99mTc-MRP20