Preparation of an imaging agent for brain tumour-radioiodinated α-methyl-1-tyrosine（AMT） and its animal studies

Li Shengli Liu Yongchang Lin Xiangtong Deng Shouzhen Li Ming

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Preparation of an imaging agent for brain tumour-radioiodinated α-methyl-1-tyrosine（AMT） and its animal studies

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- Preparation of an imaging agent for brain tumour-radioiodinated α-methyl-1-tyrosine（AMT） and its animal studies
- NUCLEAR TECHNIQUES Issue 11, (1993)
- 作者机构：
  
  1. 上海医科大学华山医院
  2. 上海医科大学药学院,上海,200040
  3. ,上海,200032
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：01 November 1993
- 稿件说明：
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[1]李圣利,刘永昌,林祥通,邓守真,李明,朱桐,钟高仁.脑瘤显像剂I-AMT的标记及动物实验[J].核技术,1993(11):669-673.

Li Shengli Liu Yongchang Lin Xiangtong Deng Shouzhen Li Ming. Preparation of an imaging agent for brain tumour-radioiodinated α-methyl-1-tyrosine（AMT） and its animal studies[J]. Nuclear techniques, 1993, (11): 669-673.
[1]李圣利,刘永昌,林祥通,邓守真,李明,朱桐,钟高仁.脑瘤显像剂I-AMT的标记及动物实验[J].核技术,1993(11):669-673. DOI：

Li Shengli Liu Yongchang Lin Xiangtong Deng Shouzhen Li Ming. Preparation of an imaging agent for brain tumour-radioiodinated α-methyl-1-tyrosine（AMT） and its animal studies[J]. Nuclear techniques, 1993, (11): 669-673. DOI：

摘要

探讨了α-甲基-1-酪氨酸（α-methyl-1-tyrosine简称AMT）的放射性碘标记、分离纯化方法及其在小白鼠体内的分布。结果显示:采用氯胺-T法或Iodogen法标记

其标记率最低为60％

最高达80％以上。采用Sephadex LH-20柱层析分离

I-AMT

其放化纯度均大于98％。

I-AMT从血中清除迅速

主要经肾脏排泄;静注给药后5、15、30、60min

每克脑组织分别占注射剂量的4.14％、2.50％、2.13％和1.24％。

Abstract

Radioiodinated AMT is a new positive imaging agent for brain tumour. In this paper

its radioiodination

purification

and biodistribution in mice is described. AMT was labelled with 125I/131I using either chloramine-T or iodogen method. The labelling rate was 60% to 80%. After column chromatography on sephadex LH-20

the radiochemical purity was greater than 98%. Animal experiments showed that 25I-AMT was eliminated from blood rapidly and was mainly excreted through kidney. 5

60 minutes after tail vein injection

the radioactivities of brain tissue per gram was 4.14%

2.50%

2.13%

1.24% of injection dose respectively.

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