Synthesis of 125I labelled derivatives of thyroxine and triiodothyronine for RIA

Tang Guozhong Zhao Xialing Zhou Meiying Yin Linxiang Yang Jianzhong Hu Gensheng

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Synthesis of 125I labelled derivatives of thyroxine and triiodothyronine for RIA

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- Synthesis of 125I labelled derivatives of thyroxine and triiodothyronine for RIA
- NUCLEAR TECHNIQUES Issue 1, (1992)
- 作者机构：
  
  1. 中国科学院上海原子核研究所
  2. 中国科学院上海原子核研究所,上海,201800
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：01 January 1992
- 稿件说明：
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[1]唐国忠,赵夏令,周美英,殷林祥,杨建忠,胡根生.碘-125标记甲状腺激素衍生物的合成[J].核技术,1992(01):46-50.

Tang Guozhong Zhao Xialing Zhou Meiying Yin Linxiang Yang Jianzhong Hu Gensheng. Synthesis of 125I labelled derivatives of thyroxine and triiodothyronine for RIA[J]. Nuclear techniques, 1992, (1): 46-50.
[1]唐国忠,赵夏令,周美英,殷林祥,杨建忠,胡根生.碘-125标记甲状腺激素衍生物的合成[J].核技术,1992(01):46-50. DOI：

Tang Guozhong Zhao Xialing Zhou Meiying Yin Linxiang Yang Jianzhong Hu Gensheng. Synthesis of 125I labelled derivatives of thyroxine and triiodothyronine for RIA[J]. Nuclear techniques, 1992, (1): 46-50. DOI：

摘要

以三碘甲腺原氨酸衍生物（T

X）和Na

125

I为原料

用氯胺-T法合成了

125

I-T

X和

125

I-T

X经HPLC分离纯化

产品的比活度:

125

I-T

X为16.87—31.78GBq/mg

125

I-T

X为31.15—46.07GBq/mg。该二种示踪剂已用于直接法放射免疫分析测定血中游离T

和游离T

浓度

并已证明

该衍生物虽经化学改性限制了与血清中内源蛋白的结合.但仍保持了T

、T

原有的与相应特异性抗体的结合特性。

Abstract

Using triiodothyronine derivative（T3X） and Na 125I as starting materials

125I-T3X and 125I-T4X were synthesized by the chloramine-T method and separated by HPLC. The specific activity of products was 16.87-31.78GBq/mg for 125I-T3X and 3] 15-46.07 GBq/mg for 125I-T4X. The tracers have been used in the direct method of RIA for free T3 and free T4 in serum. It’s proved that the derivative

chemically modified to inhibit its binding to the endogenous serum proteins

still remain original binding characteristics of T3

T4 with the specific antiserum.

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