Assay of androgen receptors in human prostate tissue

Hu Xiaoke Gui Zhining

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Assay of androgen receptors in human prostate tissue

更新时间：2021-04-09

- Assay of androgen receptors in human prostate tissue
- NUCLEAR TECHNIQUES Issue 5, (1992)
- 作者机构：
  
  1. 中山医科大学
  2. 中山医科大学广州 510089广州市红十字会医院核医学科
- 作者简介：
- 基金信息：
- DOI：
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- Published：01 May 1992
- 稿件说明：
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[1]胡笑克,桂治宁.前列腺组织雄激素受体的测定[J].核技术,1992(05):257-261.

Hu Xiaoke Gui Zhining. Assay of androgen receptors in human prostate tissue[J]. Nuclear techniques, 1992, (5): 257-261.
[1]胡笑克,桂治宁.前列腺组织雄激素受体的测定[J].核技术,1992(05):257-261. DOI：

Hu Xiaoke Gui Zhining. Assay of androgen receptors in human prostate tissue[J]. Nuclear techniques, 1992, (5): 257-261. DOI：

摘要

本室建立了雄激素受体（AR）测定的放射配基结合分析（RBA）法。测得人前列腺组织中胞浆、胞核的AR均可被约5nmol/l的双氢睾酮饱和

其最大结合容量分别为129.4fmol/mg胞浆蛋白和176.2fmol/mg胞核蛋白;平衡解离常数分别为0.88nmol/l和3.2nmol/l。人前列腺癌的胞浆胞核AR含量均高于正常前列腺及前列腺肥大的（P<0.05）。为前列腺癌病人选择治疗方案提供了理论依据。同时用融裱法放射自显影证实了AR主要分布在前列腺组织的腺区

尤其是腺上皮细胞核。

Abstract

The result of radioligand binding assay study demonstrated that in the prostate both cytoplasmic and nuclear AR can be saturated by 5 nmol/1 dihydrotestosterone （DHT）. The values of Bmax and KD are 129.4 fmol/mg protein and 0.88 nmol/1 in cytoplasm; 176.2 fmol/mg protein and 3.2 nmol/1 in nucleus. Both the cytoplasmic and nuclear AR content in prostatic cancer are higher than that in normal prostate and benign prostatic hypertrophy （P<0.05）. It is useful in selecting suitable therapy for PC patients. Thaw-mount autoradiography demonstrated that AR are mainly located in the epithelial cells of the glandular tissue of prostate.

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The study of the androgen receptor profile and changes of level of serum testosterone in human prostatic cancer

A comparative study on protein metabolism in various tissues by autoradiography

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Related Institution

Sun Yat -sen University of Medical Sciences, Guangzhou 510089)Mei Hua Zeng Jinyun

中山医科大学附属一院

510089广州市红十字会医院

510089中山医科大学肿瘤医院

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