Synthesis of new N<sub>3</sub>S pseudo-peptide complex and its biodistribution in mice

YE Haihong HAN Jiansheng LIU Chunping LI Hua ZHANG Huabei

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Synthesis of new N₃S pseudo-peptide complex and its biodistribution in mice

更新时间：2021-03-12

- Synthesis of new N₃S pseudo-peptide complex and its biodistribution in mice
- NUCLEAR TECHNIQUES Issue 11, (2005)
- 作者机构：
  
  1. 北京师范大学化学系
  2. 北京师范大学化学系,北京,100875
- 作者简介：
- 基金信息：
  
  教育部回国人员启动基金资助
- DOI：
  CLC： R817
- Published：01 November 2005
- 稿件说明：
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[1]叶海鸿,韩见生,刘春萍,李华,张华北.新骨架N_3S型肾功能显像剂的制备及其在小鼠体内的生物分布研究[J].核技术,2005(11):62-66.

YE Haihong HAN Jiansheng LIU Chunping LI Hua ZHANG Huabei. Synthesis of new N₃S pseudo-peptide complex and its biodistribution in mice[J]. Nuclear techniques, 2005, (11).
[1]叶海鸿,韩见生,刘春萍,李华,张华北.新骨架N_3S型肾功能显像剂的制备及其在小鼠体内的生物分布研究[J].核技术,2005(11):62-66. DOI：

YE Haihong HAN Jiansheng LIU Chunping LI Hua ZHANG Huabei. Synthesis of new N₃S pseudo-peptide complex and its biodistribution in mice[J]. Nuclear techniques, 2005, (11). DOI：

摘要

以巯基乙酸为初始原料

通过5步反应设计合成了一个新的N3S型类肽配体

其结构经谱学鉴定（IR

1HNMR

元素分析）;并进行了99Tcm放射性标记

研究了在小鼠体内的生物分布特征。活性实验结果表明

99Tcm-MVGQ具有较高的肾初始摄取和较快的血清除速度

肾清除很快

具有成为新型肾功能显像剂的潜力。

Abstract

A new target chelator was synthesized through five steps with mercaptoacetic acid as primitive materials

which was identified on the basis of the spectroscopic data

such as IR

1HNMR

and elementary analysis. The chela- tor was labeled with technetium 99m and its biological activities in mice given in %ID/g values were determined to explore new renal imaging agent. The bio-distribution results in mice indicate that 99Tcm-MVGQ has high kidney up- take as well as quick blood and kidney clearance

thus showing promising application as an ideal kidney imaging agent.

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Synthesis of new N3S pseudo-peptide complex and its biodistribution in mice

DOI：

摘要

Abstract

关键词

Keywords

references

Synthesis of new N₃S pseudo-peptide complex and its biodistribution in mice